Home LiteratureArticle Details
PMID: 711331 Published · ppublish English Journal Article

Susceptibility of mice to acute and persistent measles infection.

Infection and immunity ·Vol. 21 ·No. 3 ·1978-09-00 ·Pages 764-70

Neighbour PA, Rager-Zisman B, Bloom BR

Abstract

Intracerebral inoculation of neonatal mice with the Edmonston strain of measles virus produced an acute, lethal encephalitis and thymic dysplasia in susceptible mice. There was an age-related development of resistance to infection. This resistance was strain-dependent and appeared to be associated with the extent of virus growth in the brain. Studies on the genetic basis for susceptibility, using hybrid and backcross mice, revealed that the principal determinant of host resistance to acute infection was a dominant gene or genes which segregated independently of the H-2 complex. A small number of survivors of the acute infection showed persistence of measles virus antigens in the cerebellum and spleen for up to 2 months after inoculation. However, the low frequency of this persistence indicated that, at this time, intracerebral inoculation of neonatal mice with the Edmonston strain of measles virus constitutes a difficult model for the study of persistant measles infection.

MeSH Terms
Acute Disease Age Factors Animals Chronic Disease Disease Models, Animal H-2 Antigens/genetics Measles/immunology Mice Mice, Inbred Strains/microbiology Multiple Sclerosis/immunology Species Specificity Subacute Sclerosing Panencephalitis/immunology
Chemicals
H-2 Antigens
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Neighbour P A
Rager-Zisman B
Bloom B R
References (29)
29 references, click to expand
  1. INHERITANCE OF RESISTANCE TO INFLUENZA VIRUS IN MICE.
    Proc Soc Exp Biol Med. 1964 Jun;116:506-9 PMID: 14193387
  2. Measles antibodies in multiple sclerosis.
    Proc Soc Exp Biol Med. 1962 Dec;111:562-6 PMID: 14011000
  3. Measles antigen in multiple sclerosis: identification in the jejunum by immunofluorescence.
    Life Sci. 1976 Nov 15;19(10):1603-8 PMID: 994704
  4. Recovery of Paramyxovirus from the jejunum of patients with multiple sclerosis.
    Lancet. 1977 May 28;1(8022):1117-9 PMID: 68221
  5. Interactions between host and viral genomes in mouse leukemia.
    Annu Rev Genet. 1977;11:277-96 PMID: 202189
  6. Differences between the intracellular polypeptides of measles and subacute sclerosing panencephalitis virus.
    Nature. 1978 Mar 30;272(5652):458-60 PMID: 634370
  7. The relationship between direct migration inhibition with measles antigen and E rosettes in normals and patients with multiple sclerosis.
    Clin Immunol Immunopathol. 1978 Jan;9(1):63-6 PMID: 618411
  8. A procedure for the fusion of cells in suspension by means of polyethylene glycol.
    Somatic Cell Genet. 1977 Mar;3(2):227-30 PMID: 605382
  9. Growth of measles virus in nervous tissues. IV. Neurovirulence of wild measles and SSPE viruses in monkeys.
    Jpn J Med Sci Biol. 1976 Aug;29(4):177-86 PMID: 826674
  10. RNA homology between subacute sclerosing panencephalitis and measles viruses.
    Nature. 1976 Dec 2;264(5585):474-7 PMID: 1004582
  11. A useful quantitative semimicromethod for viral plaque assay.
    Proc Soc Exp Biol Med. 1973 Apr;142(4):1174-9 PMID: 4121080
  12. Subacute sclerosing panencephalitis (SSPE) agent in hamsters. II. The neuropathology of acute and chronic infections.
    Exp Mol Pathol. 1973 Jun;18(3):345-56 PMID: 4122550
  13. Age dependence of viral expression: comparative pathogenesis of two rodent-adapted strains of measles virus in mice.
    Infect Immun. 1974 Apr;9(4):690-5 PMID: 4132617
  14. Measles-virus antibody and antigen in subacute sclerosing panencephalitis.
    Lancet. 1967 Mar 11;1(7489):542-4 PMID: 4163906
  15. Subacute sclerosing panencephalitis: isolation of measles virus from a brain biopsy.
    Nature. 1969 Mar 8;221(5184):974 PMID: 5765518
  16. A suppression of cellular immunity in patients with multiple sclerosis.
    J Exp Med. 1973 Dec 1;138(6):1591-6 PMID: 4357685
  17. Histocompatibility-linked genetic control of specific immune responses to viral infection.
    Transplant Rev. 1974;19(0):209-25 PMID: 4135405
  18. Histocompatibility determinants in multiple sclerosis, with special reference to clinical course.
    Lancet. 1973 Dec 1;2(7840):1221-5 PMID: 4128558
  19. The role of genetics in Gross virus leukemogenesis.
    Bibl Haematol. 1970;(36):213-20 PMID: 4142387
  20. Slow virus diseases.
    Annu Rev Microbiol. 1974;28(0):231-4 PMID: 4372938
  21. Histocompatibility studies and multiple sclerosis.
    Arch Neurol. 1976 Jun;33(6):395-8 PMID: 1084740
  22. Genetics of natural resistance to herpesvirus infections in mice.
    Nature. 1975 Nov 13;258(5531):152-3 PMID: 171586
  23. The possible viral etiology of multiple sclerosis.
    Adv Neurol. 1975;13:1-46 PMID: 175649
  24. Host genetic control of recovery from Friend leukemia virus-induced splenomegaly: mapping of a gene within the major histocompatability complex.
    J Exp Med. 1974 Dec 1;140(6):1457-67 PMID: 4430891
  25. Histocompatibility-linked genetic control of disease susceptibility. Murine lymphocytic choriomeningitis virus infection.
    J Exp Med. 1973 May 1;137(5):1201-12 PMID: 4702099
  26. Subacute sclerosing panencephalitis: isolation of suppressed measles virus from lymph node biopsies.
    Science. 1971 Aug 27;173(3999):840-1 PMID: 4937231
  27. Experimental measles encephalitis: a genetic analysis.
    Infect Immun. 1975 Oct;12(4):785-90 PMID: 1193715
  28. The association between measles and multiple sclerosis.
    Prog Med Virol. 1975;21:158-64 PMID: 1208877
  29. Latent measles virus infection of the hamster central nervous system.
    J Immunol. 1971 Dec;107(6):1593-8 PMID: 5120399
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.21.3.764-770.1978
Published
1978-09-00
Pages
764-70
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC422063
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.21.3.764-770.1978 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2