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PMID: 7129448 Published · ppublish English Journal Article

Genetic homology and crossing over in the X and Y chromosomes of Mammals.

Human genetics ·Vol. 61 ·No. 2 ·1982-00-00 ·Pages 85-90

Burgoyne PS

Abstract

The "X-Y crossover model" described in this paper postulates the (1) the pairing observed between the X and the Y chromosome at zygotene is a consequence of genetic homology, (2) there is a single obligatory crossover between the X and Y pacing segments, and (3) the segment of the X which pairs with the Y is protected from subsequent inactivation. Genes distal to the proposed crossover ("pseudoautosomal genes") will appear to be autosomally inherited because they will be transmitted to both male and female offspring. Some criteria for identifying pseudoautosomal genes are outlined. The existence of a single obligatory crossover between the X and Y of the mouse is strongly supported by a recent demonstration that the sex-reversing mutation Sxr, which is passed equally to XX and XY offspring by male carriers, is transmitted on the sex chromosomes. Pseudoautosomally inherited genes may also be responsible for XX sex reversal in goats and familial XX sex reversal in man.

MeSH Terms
Animals Crossing Over, Genetic Dosage Compensation, Genetic Female Genes Genetic Linkage Goats/genetics Humans Male Mice/genetics Models, Genetic Mutation Phenotype Sex Chromosomes Sex Differentiation
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Burgoyne P S
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39 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00274192
Published
1982-00-00
Pages
85-90
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00274192 View journal details
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