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PMID: 7195729 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.

British journal of cancer ·Vol. 43 ·No. 6 ·1981-06-00 ·Pages 772-85

Easty DM, Easty GC, Carter RL, Monaghan P, Butler LJ

Abstract

Ten cell lines of human squamous carcinomas of the tongue and larynx have been established from surgical specimens removed from 36 unselected patients, in order to provide systems for investigating the invasive and tissue-destructive capacity of squamous carcinomas of the head and neck. The morphology, ultrastructure and growth characteristics of the 10 lines are described. Detailed cytogenetic analysis of the first 4 lines indicates that each is karyotypically unique, with no evidence of cross-contamination. Nine of the 10 cell lines secrete immunoreactive beta human chorionic gonadotrophin (beta-hCG) in the culture medium. No correlation was demonstrated between the ability of the cell lines to secrete plasminogen activator and their capacity to grow in soft agar or as xenografts in immune-deficient mice.

MeSH Terms
Aged Animals Carcinoma, Squamous Cell/genetics,metabolism,ultrastructure Cell Line Chorionic Gonadotropin/metabolism Cytoplasm/ultrastructure Female Head and Neck Neoplasms/genetics,metabolism,ultrastructure Humans Karyotyping Male Mice Microscopy, Electron Middle Aged Neoplasm Transplantation Plasminogen Activators/metabolism Transplantation, Heterologous
Chemicals
Chorionic Gonadotropin Plasminogen Activators
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Easty D M
Easty G C
Carter R L
Monaghan P
Butler L J
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24 references, click to expand
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/bjc.1981.115
Published
1981-06-00
Pages
772-85
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2010719
Subset
IM
External Links
PubMed source DOI: 10.1038/bjc.1981.115 PMC Full Text View journal details
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