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PMID: 7203527 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Diverging effects of chemotactic serum peptides and synthetic f-Met-Leu-Phe on neutrophil locomotion and adhesion.

Immunology ·Vol. 42 ·No. 3 ·1981-03-00 ·Pages 379-83

Keller HU, Wissler JH, Damerau B

Abstract

The chemotactic serum peptide preparations CAT 1.6.1. and C5adesArg induced marked directional locomotion over a wide concentration range without significant effects on random locomotion and adhesion of human neutrophils in Gey's solution containing 2% HSA. In contrast, f-Met-Leu-Phe produced marked negative chemokinetic effects and its capacity to induce directional locomotion was more limited with respect to magnitude and concentration range. The negative chemokinetic effect of f-Met-Leu-Phe correlated closely with increased spreading and cell adhesion.

MeSH Terms
Cell Adhesion/drug effects Chemotactic Factors/pharmacology Chemotaxis, Leukocyte/drug effects Complement C5/analogs & derivatives,immunology Complement C5a, des-Arginine Dose-Response Relationship, Immunologic Humans Intercellular Signaling Peptides and Proteins Methionine/analogs & derivatives N-Formylmethionine/analogs & derivatives,immunology N-Formylmethionine Leucyl-Phenylalanine Neutrophils/drug effects,immunology Oligopeptides/immunology Peptides/immunology
Chemicals
CAT 1.6.1 Chemotactic Factors Complement C5 Complement C5a, des-Arginine Intercellular Signaling Peptides and Proteins Oligopeptides Peptides N-Formylmethionine N-Formylmethionine Leucyl-Phenylalanine Methionine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Keller H U
Wissler J H
Damerau B
References (14)
14 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1981-03-00
Pages
379-83
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1458440
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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