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PMID: 7272458 Published · ppublish English Journal Article

Modeling repetitive firing and bursting in a small unmyelinated nerve fiber.

Biophysical journal ·Vol. 35 ·No. 3 ·1981-09-00 ·Pages 715-30

Scriven DR

Abstract

The Hodgkin-Huxley equations, originally developed to describe the electrical events in the squid giant axon, have been modified to simulate the ionic and electrical events in a small unmyelinated nerve fiber. The modified equations incorporate an electrogenic sodium-potassium pump, finite intra-axonal volume, a periaxonal space, a calcium current, and calcium-dependent potassium conductance (GKCa). The model shows that adaptation can occur in two ways: increased Na-K pump activity because of periaxonal K accumulation or intra-axonal Na accumulation; or from an increase in (GKCa) caused by calcium accumulating within the axon. Bursting is an extension of adaptation and occurs when the sensitivity of the Na-K pump or (GKCa) to changes in ionic concentration is increased.

MeSH Terms
Animals Axons/physiology Biological Transport, Active Calcium/pharmacology Decapodiformes Mathematics Membrane Potentials Models, Biological Potassium/metabolism Sodium/metabolism
Chemicals
Sodium Potassium Calcium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Scriven D R
References (26)
26 references, click to expand
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(81)84823-0
Published
1981-09-00
Pages
715-30
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1327559
Subset
IM
External Links
PubMed source DOI: 10.1016/S0006-3495(81)84823-0 PMC Full Text View journal details
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