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PMID: 728113 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Evidence for a reciprocal relationship between lipogenesis and ketogenesis in hepatocytes from fed virgin and lactating rats.

The Biochemical journal ·Vol. 176 ·No. 1 ·1978-10-15 ·Pages 331-4

Benito M, Williamson DH

Abstract

Lipogenesis is increased in hepatocytes from fed lactating rats compared with virgin rats. Inhibition of lipogenesis with 5-(tetradecyloxy)-2-furoic acid resulted in increased ketogenesis from endogenous substrate, but not from oleate. Dihydroxyacetone increased ketogenesis from endogenous substrate, but not from oleate. Dihydroxyacetone increased lipogenesis and esterification of [1--14C]oleate and decreased ketogenesis; these changes were reversed by the inhibitor. The reciprocal relationship between lipogenesis and ketogenesis in hepatocytes from fed rats may be due to alterations in [malonyl-CoA] [McGarry, Mannaerts & Foster (1977) J. Clin. Invest. 60, 265--270; Cook, King & Veech (1978) J. Biol. Chem. 253, 2529--2531], but this mechanism is not considered to be sufficient to explain the increased ketogenesis in starvation completely.

MeSH Terms
Animals Carboxylic Acids/pharmacology Female Furans/pharmacology In Vitro Techniques Ketone Bodies/biosynthesis Lactation Lipids/biosynthesis Liver/cytology,drug effects,metabolism Oleic Acids/metabolism Pregnancy Rats
Chemicals
Carboxylic Acids Furans Ketone Bodies Lipids Oleic Acids
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Benito M
Williamson D H
References (18)
18 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1760331
Published
1978-10-15
Pages
331-4
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1186232
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1760331 PMC Full Text View journal details
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