Home LiteratureArticle Details
PMID: 7409364 Published · ppublish English Journal Article

HLA genotype studies in juvenile insulin-dependent diabetes.

Diabetologia ·Vol. 19 ·No. 3 ·1980-09-00 ·Pages 189-93

Deschamps I, Lestradet H, Bonaïti C, Schmid M, Busson M, Benajam A, Marcelli-Barge A, Hors J

Abstract

HLA genotypes were ascertained in 53 French Caucasian families, comprising 68 juvenile onset insulin-dependent diabetic siblings. Among the 49 alleles detected at different loci in the HLA complex (A, C, B, Bf, DR) 4 appeared to occur at a significantly higher frequency among the 53 index cases than in a control series of 116 healthy individuals: HLA-B18 (p < 10(-3)), DRw3, DRw4 and BfF1 (p < 10(-6)). The excess of HLA identical affected siblings confirms genotype disequilibrium and supports the hypothesis of an HLA-linked gene(s) conferring susceptibility. There was no increase of homozygosity for HLA DRw3 and DRw4 whereas there was a marked excess heterozygosity for HLA DRw3/DRw4 in diabetic patients (32% versus 0% in the control series, p < 0.001). These data provide evidence for the existence of two cooperating genes, linked to each of the HLA DR alleles.

MeSH Terms
Alleles Diabetes Mellitus, Type 1/genetics,immunology Gene Frequency Genetic Carrier Screening HLA Antigens/genetics Homozygote Humans Recombination, Genetic
Chemicals
HLA Antigens
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Deschamps I
Lestradet H
Bonaïti C
Schmid M
Busson M
Benajam A
Marcelli-Barge A
Hors J
References (34)
34 references, click to expand
  1. A haplotype study of HLA complex with special reference to the HLA-DR series and to Bf. C2 and glyoxalase I polymorphisms.
    Tissue Antigens. 1978 Oct;12(4):297-307 PMID: 83027
  2. The histocompatibility system in juvenile, insulin-dependent diabetic multiplex kindreds.
    J Clin Invest. 1977 Nov;60(5):989-98 PMID: 908763
  3. Studies of the HLA system and insulin-dependent diabetes mellitus.
    Diabetes Care. 1979 Mar-Apr;2(2):209-14 PMID: 520125
  4. HLA haplotype study of 53 juvenile insulin-dependent diabetic (I.D.D.) families.
    Tissue Antigens. 1982 Aug;20(2):123-40 PMID: 6814007
  5. Seventh allele of the HLA-C series (Cve).
    Transplant Proc. 1979 Mar;11(1):613-5 PMID: 452102
  6. HLA and DRW antigens in insulin-dependent diabetes.
    Br Med J. 1978 Apr 1;1(6116):823-4 PMID: 305802
  7. Heterogeneity in diabetes mellitus--update, 1978. Evidence for further genetic heterogeneity within juvenile-onset insulin-dependent diabetes mellitus.
    Diabetes. 1978 May;27(5):599-605 PMID: 348539
  8. HLA antigens and insulin dependent diabetes mellitus. A family study.
    Diabete Metab. 1977 Dec;3(4):259-62 PMID: 413751
  9. HLA-typing in juvenile diabetics with and without positive family history and in families with one and two diabetic siblings.
    Diabetologia. 1978 Dec;15(6):447-51 PMID: 720778
  10. HL-A antigens in insulin-dependent diabetes mellitus.
    Nouv Presse Med. 1976 Jun 26;5(26):1628-30 PMID: 133329
  11. Genetic marker for insulin-dependent diabetes mellitus.
    Lancet. 1979 Jun 9;1(8128):1208-10 PMID: 87677
  12. Nomenclature for factors of the HLA system--1977.
    Vox Sang. 1978 Jul-Aug;35(1-2):111-6 PMID: 78582
  13. Increased frequency of HLA--Dw3 in North-American black patients with juvenile onset diabetes.
    Tissue Antigens. 1979 May;13(5):369-72 PMID: 91214
  14. Juvenile-onset diabetes HLA-A, -B, -C, and -DR alloantigens.
    Diabetes. 1979 Jan;28(1):1-4 PMID: 759244
  15. Genetics of juvenile diabetes mellitus. A recessive gene closely linked to HLA D and with 50 per cent penetrance.
    N Engl J Med. 1977 Nov 10;297(19):1036-40 PMID: 909549
  16. Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test.
    Transplantation. 1968 Nov;6(8):913-27 PMID: 5696820
  17. HLA genetic heterogeneity in diabetes mellitus.
    Br Med Bull. 1978 Sep;34(3):285-9 PMID: 82462
  18. [Insulin-dependent diabetes and HLA].
    Journ Annu Diabetol Hotel Dieu. 1977;:78-94 PMID: 894881
  19. Evidence for HL-A-linked genes in "juvenile" diabetes mellitus.
    Br Med J. 1975 Jul 19;3(5976):133-5 PMID: 1139259
  20. The importance of HLA genes to susceptibility in the development of juvenile diabetes mellitus. A study of 93 patients and 68 first degree blood relations.
    Diabete Metab. 1977 Mar;3(1):43-8 PMID: 870354
  21. Leukocyte antigens and disease: III. Association of HLA-B8 and HLA-BW 15 with insulin-dependent diabetes in three different population groups.
    Metabolism. 1977 May;26(5):487-92 PMID: 850480
  22. The HLA system in the families of patients with juvenile diabetes mellitus.
    J Exp Med. 1976 May 1;143(5):1277-82 PMID: 1262788
  23. Insulin-dependent diabetes mellitus and properdin factor B.
    Lancet. 1979 Aug 18;2(8138):369-70 PMID: 89438
  24. Genetic susceptibility in diabetes mellitus: analysis of the HLA association.
    Br Med J. 1976 Oct 9;2(6040):846-8 PMID: 990715
  25. Application of the lod score method to detection of linkage between HLA and juvenile insulin-dependent diabetes.
    Clin Genet. 1980 Jul;18(1):51-7 PMID: 6998613
  26. Properdin factor B alleles as markers for insulin-dependent diabetes.
    Lancet. 1979 Oct 13;2(8146):793 PMID: 90883
  27. Genetic polymorphism in human glycine-rich beta-glycoprotein.
    J Exp Med. 1972 Jan;135(1):68-80 PMID: 4109808
  28. Role of HLA-B8 and Bw15 antigens in diabetic children.
    N Engl J Med. 1977 Feb 17;296(7):397 PMID: 834204
  29. The association of HLA with juvenile diabetes mellitus in Newfoundland.
    Tissue Antigens. 1978 Sep;12(3):215-22 PMID: 83020
  30. HLA, islet cell antibodies, and types of diabetes mellitus.
    Diabetes. 1978;27 Suppl 1:247-50 PMID: 344116
  31. HLA antigens in Sardinian patients with diabetes mellitus.
    Diabete Metab. 1977 Dec;3(4):263-7 PMID: 598567
  32. HL-A and disease associations--a survey.
    Transplant Rev. 1975;22:3-43 PMID: 46644
  33. MLC typing in juvenile diabetes mellitus and idiopathic Addison's disease.
    Transplant Rev. 1975;22:125-47 PMID: 46642
  34. B-lymphocyte alloantigens and insulin-dependent diabetes mellitus.
    Lancet. 1977 Nov 26;2(8048):1128 PMID: 73030
Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF00275267
Published
1980-09-00
Pages
189-93
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00275267 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2