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PMID: 7425602 Published · ppublish English Journal Article

Effects of tetracycline on the streptococcal flora of periodontal pockets.

Antimicrobial agents and chemotherapy ·Vol. 17 ·No. 3 ·1980-03-00 ·Pages 372-8

Hawley RJ, Lee LN, LeBlanc DJ

Abstract

The effects of tetracycline on the subgingival streptococcal flora of periodontal patients were examined. Before antibiotic treatment, tetracycline-resistant isolates were obtained from 24 to 25 patients. In most patients, the proportion of the subgingival flora resistant to tetracycline increased after 2 weeks of therapy (1,000 mg of tetracycline/day) and then decreased after the cessation of treatment. Cultural conditions used for primary isolation were designed to favor the growth of facultative streptococci. Consequently, the majority (99%) of resistant isolates were identified as streptococci. Among 407 tetracycline-resistant Streptococcus isolates chosen for further classification, 9 species were identified, with S. sanguis (63%) and S. mitis (19%) predominating. There were no significant differences in the distribution of species isolated before and after treatment and after the cessation of tetracycline treatment. Plasmids were isolated from only 23 of 121 resistant streptococcal strains examined, suggesting that tetracycline resistance is not plasmid mediated in the majority of these oral streptococci.

MeSH Terms
DNA, Bacterial/analysis Drug Resistance, Microbial Humans Periodontal Pocket/drug therapy,microbiology Periodontitis/microbiology R Factors Species Specificity Streptococcus/analysis,classification,drug effects Tetracycline/pharmacology,therapeutic use
Chemicals
DNA, Bacterial Tetracycline
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hawley R J
Lee L N
LeBlanc D J
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34 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.17.3.372
Published
1980-03-00
Pages
372-8
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC283793
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.17.3.372 PMC Full Text View journal details
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