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PMID: 7427778 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

The inheritance pattern of factor XII (Hageman) deficiency in domestic cats.

Canadian journal of comparative medicine : Revue canadienne de medecine comparee ·Vol. 44 ·No. 3 ·1980-07-00 ·Pages 309-14

Kier AB, Bresnahan JF, White FJ, Wagner JE

Abstract

Measurements of coagulation factor XII levels in F1 progeny of a cat having factor XII deficiency revealed an autosomal recessive pattern similar to that reported in humans (Hageman trait). A study of the pedigree of the colony revealed that F1 kittens had approximately 50% factor XII activity while kittens produced by backcrossing with an F1 progeny possessed an average of 50% and a less than 2% factor XII activity in an approximate 1:1 ratio. Kittens having an average of 50% factor XII activity were postulated heterozygous for the trait while progeny with less than 2% activity were considered genetically homozygous.

MeSH Terms
Animals Cat Diseases/genetics Cats Crosses, Genetic Factor XII/analysis Factor XII Deficiency/genetics,veterinary Female Genes, Recessive Male Pedigree
Chemicals
Factor XII
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kier A B
Bresnahan J F
White F J
Wagner J E
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24 references, click to expand
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Article Info
Journal
Canadian journal of comparative medicine : Revue canadienne de medecine comparee
Abbr.
Can J Comp Med
ISSN
0008-4050
Published
1980-07-00
Pages
309-14
Language
English
Region
Canada
NLM ID
0151747
PMCID
PMC1320079
Subset
IM
Grants
NCRR NIH HHS · RR0471 · United States
NCRR NIH HHS · RR05009 · United States
NCRR NIH HHS · RR07004 · United States
External Links
PubMed source PMC Full Text
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