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PMID: 7439958 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Genetic and structural characterization of H-2-controlled allelic forms of murine C4.

Immunogenetics ·Vol. 11 ·No. 1 ·1980-07-00 ·Pages 55-63

Parker KL, Atkinson JP, Roos MH, Shreffler DC

Abstract

The patterns of expression of several types of genetic variation in murine C4 were investigated. Dominance was assessed for S-region-determined differences in molecular weight of the C4 alpha-chain from Sw7 strains relative to all other strains examined and in C4 hemolytic titers. Codominant expression in F1 hybrids was shown for both of the above variations. Comparison of tryptic peptide profiles of radiolabeled C4 beta-chains encoded by different S regions revealed differences in their primary structures. The demonstration of codominant expression for the variant C4 traits examined and the evidence from tryptic peptide maps for haplotype differences in C4 primary structure strongly support the hypothesis that polymorphism of murine C4 is controlled by structural genes which are located in the S region.

MeSH Terms
Alleles Animals Chromosome Mapping Complement C4/genetics Genes Genes, Dominant Genetic Variation Mice Mice, Inbred Strains/genetics Molecular Weight Phenotype Protein Conformation Protein Precursors/genetics
Chemicals
Complement C4 Protein Precursors
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Parker K L
Atkinson J P
Roos M H
Shreffler D C
References (18)
18 references, click to expand
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF01567769
Published
1980-07-00
Pages
55-63
Language
English
Region
United States
NLM ID
0420404
Subset
IM
Grants
NIAID NIH HHS · AI 12734 · United States
NIAID NIH HHS · AI 15353 · United States
NIGMS NIH HHS · GM 07200 · United States
External Links
PubMed source DOI: 10.1007/BF01567769 View journal details
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