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PMID: 7463557 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus.

Journal of virology ·Vol. 36 ·No. 3 ·1980-12-00 ·Pages 829-36

Mason WS, Seal G, Summers J

Abstract

A virus found in the sera of Pekin ducks appears to be a new member of the human hepatitis B-like family of viruses. This virus had a diameter of 40 nm and an appearance in the electron microscope similar to that of human hepatitis B virus. The DNA genome of the virus was circular and partially single stranded, and an endogenous DNA polymerase associated with the virus was capable of converting the genome to a double-stranded circle with a size of ca. 3,000 base pairs. An analysis for viral DNA in the organs of infected birds indicated preferential localization in the liver, implicating this organ as the site of virus replication. In all of these aspects, the virus bears a striking resemblance to human hepatitis B virus and appears to be a new member of this family, which also includes ground squirrel hepatitis virus and woodchuck hepatitis virus.

MeSH Terms
Animals DNA, Viral/analysis Ducks/microbiology Hepatitis B virus/genetics Hepatitis Viruses/classification,genetics,ultrastructure Liver/analysis,microbiology Microscopy, Electron Nucleic Acid Conformation
Chemicals
DNA, Viral
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Mason W S
Seal G
Summers J
References (14)
14 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.36.3.829-836.1980
Published
1980-12-00
Pages
829-36
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC353710
Subset
IM
Grants
NIAID NIH HHS · AI15166 · United States
NCI NIH HHS · CA06927 · United States
NCI NIH HHS · CA26012 · United States
External Links
PubMed source DOI: 10.1128/JVI.36.3.829-836.1980 PMC Full Text View journal details
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