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PMID: 7493021 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Transforming growth factor-beta 3 is required for secondary palate fusion.

Nature genetics ·Vol. 11 ·No. 4 ·1995-12-00 ·Pages 409-14

Proetzel G, Pawlowski SA, Wiles MV, Yin M, Boivin GP, Howles PN, Ding J, Ferguson MW, Doetschman T

Abstract

Mice lacking TGF-beta 3 exhibit an incompletely penetrant failure of the palatal shelves to fuse leading to cleft palate. The defect appears to result from impaired adhesion of the apposing medial edge epithelia of the palatal shelves and subsequent elimination of the mid-line epithelial seam. No craniofacial abnormalities were observed. This result demonstrates that TGF-beta 3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.

MeSH Terms
Animals Base Sequence Cleft Palate/embryology,genetics Cytoskeletal Proteins/analysis DNA-Binding Proteins/analysis Extracellular Matrix Proteins/analysis Goosecoid Protein Homeodomain Proteins Mesoderm Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Morphogenesis Palate/chemistry,embryology Repressor Proteins Transcription Factors Transforming Growth Factor beta/analysis,physiology
Chemicals
Cytoskeletal Proteins DNA-Binding Proteins Extracellular Matrix Proteins Goosecoid Protein Gsc protein, mouse Homeodomain Proteins Repressor Proteins Transcription Factors Transforming Growth Factor beta
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Proetzel G
Department of Molecular Genetics, Biochemistry & Microbiology, University of Cincinnati College of Medicine, Ohio 45267, USA.
Pawlowski S A
Wiles M V
Yin M
Boivin G P
Howles P N
Ding J
Ferguson M W
Doetschman T
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Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1061-4036
DOI
10.1038/ng1295-409
Published
1995-12-00
Pages
409-14
Language
English
Region
United States
NLM ID
9216904
PMCID
PMC3855390
Subset
IM
Grants
NICHD NIH HHS · R01 HD026471 · United States
NICHD NIH HHS · HD26471 · United States
NHLBI NIH HHS · HL41496 · United States
NHLBI NIH HHS · HL46826 · United States
External Links
PubMed source DOI: 10.1038/ng1295-409 PMC Full Text View journal details
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