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PMID: 7494344 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

The Epstein-Barr virus nuclear antigen leader protein associates with hsp72/hsc73.

Journal of virology ·Vol. 69 ·No. 12 ·1995-12-00 ·Pages 8169-72

Mannick JB, Tong X, Hemnes A, Kieff E

Abstract

Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) is important for primary B-lymphocyte growth transformation. We now demonstrate that the W repeat-encoded domain of EBNA-LP significantly associates with proteins of the heat shock protein 70 family (hsp72/hsc73). hsp72/hsc73 may mediate the previously observed interaction between EBNA-LP and the retinoblastoma protein or p53.

MeSH Terms
Amino Acid Sequence Antigens, Viral/biosynthesis,isolation & purification,metabolism B-Lymphocytes/immunology,physiology,virology Cell Line DNA-Binding Proteins/biosynthesis,isolation & purification,metabolism Electrophoresis, Polyacrylamide Gel Epstein-Barr Virus Nuclear Antigens Gene Expression HSC70 Heat-Shock Proteins HSP70 Heat-Shock Proteins HSP72 Heat-Shock Proteins Heat-Shock Proteins/chemistry,isolation & purification,metabolism Humans Lymphocyte Activation Methionine/metabolism Molecular Sequence Data Protein Binding Recombinant Proteins/biosynthesis,isolation & purification,metabolism Retinoblastoma Protein/metabolism Trans-Activators/isolation & purification,metabolism Tumor Suppressor Protein p53/metabolism
Chemicals
Antigens, Viral DNA-Binding Proteins Epstein-Barr Virus Nuclear Antigens HSC70 Heat-Shock Proteins HSP70 Heat-Shock Proteins HSP72 Heat-Shock Proteins HSPA8 protein, human Heat-Shock Proteins Recombinant Proteins Retinoblastoma Protein Trans-Activators Tumor Suppressor Protein p53 Methionine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Mannick J B
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA.
Tong X
Hemnes A
Kieff E
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23 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.69.12.8169-8172.1995
Published
1995-12-00
Pages
8169-72
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC189776
Subset
IM
Grants
NIAID NIH HHS · AI00996-01 · United States
NCI NIH HHS · CA47006 · United States
External Links
PubMed source DOI: 10.1128/JVI.69.12.8169-8172.1995 PMC Full Text View journal details
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