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PMID: 7614935 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Workshop on perinatal exposure to dioxin-like compounds. I. Summary.

Environmental health perspectives ·Vol. 103 Suppl 2 ·1995-03-00 ·Pages 135-42

Lindström G, Hooper K, Petreas M, Stephens R, Gilman A

Abstract

An international workshop reviewed 20 ongoing or recently completed studies of the effects of perinatal exposures to dioxins, dibenzofurans, and PCBs on the reproductive, endocrine, neurodevelopmental, and immune systems. Many of the observed effects are consistent with these compounds acting as "environmental hormones" or endocrine disrupters. This report summarizes the conclusions and future directions described at the workshop.

MeSH Terms
Animals Brain/drug effects Female Fetus/drug effects Humans Immune System/drug effects Polychlorinated Dibenzodioxins/toxicity Pregnancy Reproduction/drug effects
Chemicals
Polychlorinated Dibenzodioxins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Lindström G
Hazardous Materials Laboratory, Cal EPA, Berkeley 94704, USA.
Hooper K
Petreas M
Stephens R
Gilman A
References (27)
27 references, click to expand
  1. Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects of maternal factors and previous lactation.
    Am J Public Health. 1986 Feb;76(2):172-7 PMID: 3080910
  2. Partial demasculinization and feminization of sex behavior in male rats by in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin is not associated with alterations in estrogen receptor binding or volumes of sexually differentiated brain nuclei.
    Toxicol Appl Pharmacol. 1994 Aug;127(2):258-67 PMID: 8048069
  3. Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects on growth, morbidity, and duration of lactation.
    Am J Public Health. 1987 Oct;77(10):1294-7 PMID: 3115123
  4. Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan.
    Science. 1988 Jul 15;241(4863):334-6 PMID: 3133768
  5. Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk.
    J Pediatr. 1988 Dec;113(6):991-5 PMID: 3142988
  6. Lymphocyte stem cell alterations following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
    Mol Pharmacol. 1989 Jan;35(1):18-25 PMID: 2783621
  7. Delayed spatial alternation deficits resulting from perinatal PCB exposure in monkeys.
    Arch Toxicol. 1988;62(4):267-73 PMID: 3149182
  8. Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children.
    J Pediatr. 1990 Jan;116(1):38-45 PMID: 2104928
  9. Effects of exposure to PCBs and related compounds on growth and activity in children.
    Neurotoxicol Teratol. 1990 Jul-Aug;12(4):319-26 PMID: 2118230
  10. Prothymocyte activity is reduced by perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure.
    J Pharmacol Exp Ther. 1990 Oct;255(1):128-32 PMID: 2213547
  11. Comparison of effects of Aroclors 1016 and 1260 on non-human primate catecholamine function.
    Toxicology. 1991 Feb;66(2):145-63 PMID: 2014516
  12. Effects of perinatal polychlorinated biphenyls and dichlorodiphenyl dichloroethene on later development.
    J Pediatr. 1991 Jul;119(1 Pt 1):58-63 PMID: 1906100
  13. CO2 breath tests using 14C-caffeine, 14C-methacetin and 14C-phenacetin for assessing postnatal development of monooxygenase activities in rats and marmosets.
    Dev Pharmacol Ther. 1991;16(3):164-75 PMID: 1914790
  14. Use of the lesion model for examining toxicant effects on cognitive behavior.
    Neurotoxicol Teratol. 1992 Mar-Apr;14(2):131-41 PMID: 1593987
  15. Impact of maternal seafood diet on fetal exposure to mercury, selenium, and lead.
    Arch Environ Health. 1992 May-Jun;47(3):185-95 PMID: 1596101
  16. Neurotoxicology of PCBs and related compounds.
    Neurotoxicology. 1992 Spring;13(1):27-35 PMID: 1508429
  17. Polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 4. Effects of multiple-dose treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on peripheral lymphocyte subpopulations of a non-human primate (Callithrix jacchus).
    Arch Toxicol. 1992;66(4):250-9 PMID: 1514923
  18. Cognitive development of Yu-Cheng ("oil disease") children prenatally exposed to heat-degraded PCBs.
    JAMA. 1992 Dec 9;268(22):3213-8 PMID: 1433761
  19. Integrated approach for evaluating species and interindividual differences in responsiveness to dioxins and structural analogs.
    Environ Health Perspect. 1992 Nov;98:125-32 PMID: 1336723
  20. Effects of perinatal exposure to specific PCB congeners on thyroid hormone concentrations and thyroid histology in the rat.
    Toxicol Lett. 1993 Jun;68(3):311-23 PMID: 8516785
  21. Effects of small doses of dioxins on the immune system of marmosets and rats.
    Ann N Y Acad Sci. 1993 Jun 23;685:662-86 PMID: 8363273
  22. Endometriosis in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
    Fundam Appl Toxicol. 1993 Nov;21(4):433-41 PMID: 8253297
  23. PCBs, DDE, and child development at 18 and 24 months.
    Ann Epidemiol. 1991 Aug;1(5):407-13 PMID: 1669521
  24. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral immunity and lymphocyte subpopulations: differences between mice and rats.
    Toxicol Appl Pharmacol. 1994 Feb;124(2):248-56 PMID: 8122270
  25. The neurochemical effects of PCB exposure are age-dependent.
    Arch Toxicol Suppl. 1994;16:128-37 PMID: 8192574
  26. Effects of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on responsiveness of the male rat reproductive system to testosterone stimulation in adulthood.
    Toxicol Appl Pharmacol. 1994 Aug;127(2):250-7 PMID: 8048068
  27. Neonatal effects of transplacental exposure to PCBs and DDE.
    J Pediatr. 1986 Aug;109(2):335-41 PMID: 3090217
Article Info
Journal
Environmental health perspectives
Abbr.
Environ Health Perspect
ISSN
0091-6765
DOI
10.1289/ehp.103-1518837
Published
1995-03-00
Pages
135-42
Language
English
Region
United States
NLM ID
0330411
PMCID
PMC1518837
Subset
IM
External Links
PubMed source DOI: 10.1289/ehp.103-1518837 PMC Full Text View journal details
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