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PMID: 7683413 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 90 ·No. 9 ·1993-05-01 ·Pages 3948-52

Clevidence DE, Overdier DG, Tao W, Qian X, Pani L, Lai E, Costa RH

Abstract

Hepatocyte nuclear factor (HNF)-3 alpha, -3 beta, and -3 gamma are liver transcription factors that mediate the coordinate expression of a number of hepatocyte-specific genes. The HNF-3 proteins share DNA-binding-domain homology among themselves and with the Drosophila homeotic protein forkhead (fkh). The HNF-3/fkh DNA-binding domain constitutes an uncharacterized protein motif that recognizes its cognate DNA binding site as a monomer. Additional HNF-3/fkh-related proteins are known to be required for determination events during embryogenesis in Drosophila and Xenopus. In this report, we describe the isolation of nine additional HNF-3/fkh homologue (HFH) clones from rodent tissue cDNAs by using both low-stringency hybridization and a polymerase chain reaction protocol. Many of the HFH genes exhibit a tissue-restricted expression pattern and are transcribed in tissues other than liver, including brain, kidney, lung, and intestine. The HNF-3/fkh motif therefore comprises a large gene family of transcription factors that play a role in tissue-specific gene regulation and development.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Blotting, Northern DNA/metabolism DNA-Binding Proteins/genetics,metabolism Drosophila/genetics Gene Library Hepatocyte Nuclear Factor 3-alpha Hepatocyte Nuclear Factor 3-beta Hepatocyte Nuclear Factor 3-gamma Humans Lung/metabolism Molecular Sequence Data Mutagenesis, Site-Directed Nuclear Proteins/genetics,metabolism Oligodeoxyribonucleotides Oligonucleotides, Antisense Organ Specificity Polymerase Chain Reaction/methods RNA/genetics,isolation & purification Rats Restriction Mapping Sequence Homology, Amino Acid Transcription Factors/genetics,metabolism
Chemicals
DNA-Binding Proteins FOXA1 protein, human FOXA2 protein, human FOXA3 protein, human Foxa1 protein, rat Foxa2 protein, rat Foxa3 protein, rat Hepatocyte Nuclear Factor 3-alpha Nuclear Proteins Oligodeoxyribonucleotides Oligonucleotides, Antisense Transcription Factors Hepatocyte Nuclear Factor 3-gamma Hepatocyte Nuclear Factor 3-beta RNA DNA
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Clevidence D E
Department of Biochemistry (M/C 536), University of Illinois College of Medicine, Chicago 60612.
Overdier D G
Tao W
Qian X
Pani L
Lai E
Costa R H
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.90.9.3948
Published
1993-05-01
Pages
3948-52
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC46423
Subset
IM
Grants
NIGMS NIH HHS · GM43241 · United States
Databases
GENBANK
L13192, L13193, L13201, L13202, L13203, L13204, L13205, L13206, L13207
External Links
PubMed source DOI: 10.1073/pnas.90.9.3948 PMC Full Text View journal details
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