Home LiteratureArticle Details
PMID: 7689224 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Six members of the mouse forkhead gene family are developmentally regulated.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 90 ·No. 16 ·1993-08-15 ·Pages 7628-31

Kaestner KH, Lee KH, Schlöndorff J, Hiemisch H, Monaghan AP, Schütz G

Abstract

The 110-aa forkhead domain defines a class of transcription factors that have been shown to be developmentally regulated in Drosophila melanogaster and Xenopus laevis. The forkhead domain is necessary and sufficient for target DNA binding as shown for the rat hepatic nuclear factor 3 (HNF3) gene family. We have cloned six forkhead gene family members from a mouse genomic library in addition to the mouse equivalents of the genes for HNF3 alpha, -beta, and -gamma. The six genes, termed fkh-1 to fkh-6, share a high degree of similarity with the Drosophila forkhead gene, having 57-67% amino acid identity within the forkhead domain. fkh-1 seems to be the mammalian homologue of the Drosophila FD1 gene, as the sequences are 86% identical. fkh-1 to fkh-6 show distinct spatial patterns of expression in adult tissues and are expressed during embryogenesis.

Related Genes
fkh-1 fkh-2 fkh-3 fkh-4 fkh-5 fkh-6
MeSH Terms
Amino Acid Sequence Animals Base Sequence Cell Line Drosophila melanogaster/genetics Embryo, Mammalian Embryo, Nonmammalian Embryonic and Fetal Development Female Gene Expression Regulation Genomic Library Male Mice/genetics Molecular Sequence Data Multigene Family Oligodeoxyribonucleotides Organ Specificity Polymerase Chain Reaction/methods RNA/biosynthesis,isolation & purification Rats Sequence Homology, Amino Acid Stem Cells Transcription Factors/genetics Transcription, Genetic Xenopus laevis/genetics
Chemicals
Oligodeoxyribonucleotides Transcription Factors RNA
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Kaestner K H
Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg.
Lee K H
Schlöndorff J
Hiemisch H
Monaghan A P
Schütz G
References (23)
23 references, click to expand
  1. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
    Anal Biochem. 1983 Jul 1;132(1):6-13 PMID: 6312838
  2. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
    Biochemistry. 1979 Nov 27;18(24):5294-9 PMID: 518835
  3. The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium.
    J Embryol Exp Morphol. 1985 Jun;87:27-45 PMID: 3897439
  4. Construction and characterization of a genomic library in lambda.
    Methods Enzymol. 1987;152:190-9 PMID: 2958678
  5. The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.
    Science. 1988 Jun 24;240(4860):1759-64 PMID: 3289117
  6. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins.
    Cell. 1989 Mar 10;56(5):777-83 PMID: 2493990
  7. The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo.
    Cell. 1989 May 19;57(4):645-58 PMID: 2566386
  8. Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase.
    J Biol Chem. 1989 Sep 5;264(25):14755-61 PMID: 2570068
  9. Eukaryotic transcriptional regulatory proteins.
    Annu Rev Biochem. 1989;58:799-839 PMID: 2673023
  10. The fork head domain: a novel DNA binding motif of eukaryotic transcription factors?
    Cell. 1990 Nov 2;63(3):455-6 PMID: 2225060
  11. HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally.
    Genes Dev. 1990 Aug;4(8):1427-36 PMID: 2227418
  12. Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.
    Genes Dev. 1991 Mar;5(3):416-27 PMID: 1672118
  13. Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat.
    Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7739-43 PMID: 1909027
  14. A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain.
    Genes Dev. 1992 Apr;6(4):599-608 PMID: 1559610
  15. The complete DNA sequence of yeast chromosome III.
    Nature. 1992 May 7;357(6373):38-46 PMID: 1574125
  16. Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain.
    Neuron. 1992 May;8(5):957-66 PMID: 1350202
  17. Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF.
    Genomics. 1992 Jul;13(3):658-64 PMID: 1639393
  18. Transcription factors: structural families and principles of DNA recognition.
    Annu Rev Biochem. 1992;61:1053-95 PMID: 1497306
  19. Developmentally regulated Drosophila gene family encoding the fork head domain.
    Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8754-8 PMID: 1356269
  20. Activin A induced expression of a fork head related gene in posterior chordamesoderm (notochord) of Xenopus laevis embryos.
    Mech Dev. 1992 Aug;38(2):157-65 PMID: 1358174
  21. Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis.
    Development. 1992 Sep;116(1):81-93 PMID: 1483397
  22. Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.
    Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52 PMID: 7683413
  23. Genomic sequencing.
    Proc Natl Acad Sci U S A. 1984 Apr;81(7):1991-5 PMID: 6326095
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.90.16.7628
Published
1993-08-15
Pages
7628-31
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC47195
Subset
IM
Databases
GENBANK
X71939, X71940, X71941, X71942, X71943, X71944
External Links
PubMed source DOI: 10.1073/pnas.90.16.7628 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2