Abstract
This study was carried out to test the hypothesis that, in chronic hepatitis (CH), inflammatory processes, including viral replication, host immune response, and hepatocyte destruction, are regulated by a cytokine network in the liver. Expression of the mRNA of the cytokines IL1-beta, IL2, IL4, IL5, IL6, TNF-alpha, and IFN-gamma, the lymphocyte markers CD4 and CD8, and the HLA class I molecule, beta 2-microglobulin (B2MG) in the liver tissue of 20 CH(C) cases and 9 CH(B) patients was investigated by the reverse transcription polymerase chain reaction (RT-PCR) method. TNF-alpha, CD4, and B2MG mRNA were detected in 100% of cases of in both CH(B) and CH(C). The expression rates of IL1-beta, IL2, IL4, IFN-gamma, and CD8 mRNA were 80%, 40%, 25%, 40%, and 80% in CH(C) and 88.9%, 44.5%, 30%, 55.6%, and 100% in CH(B). IL6 mRNA was detected only in CH(B), in 22.2% of cases, IL5 mRNA was not detected in either CH(B) or CH(C). IL2, IL4, and IFN-gamma mRNA were expressed significantly more frequently in patients who had high serum ALT and a high histological activity index (HAI) score. There was no difference in cytokine expression between CH(B) and CH(C), except in IL6, suggesting the existence of a common immunopathogenesis for CH(B) and CH(C). In chronic viral hepatitis, IL1-beta and TNF-alpha appear to play a major role in immune responses and IL2, IL4, and IFN-gamma seem to be associated with increased cytotoxic T cell response.(ABSTRACT TRUNCATED AT 250 WORDS)
MeSH Terms
Adult
Alanine Transaminase/blood
Antigens, CD/genetics
Base Sequence
Chi-Square Distribution
Chronic Disease
Cytokines/genetics
Female
Hepatitis B/immunology,metabolism,pathology
Hepatitis C/immunology,metabolism,pathology
Humans
Interferon-gamma/genetics
Interleukin-1/genetics
Interleukin-2/genetics
Interleukin-4/genetics
Interleukin-6/genetics
Liver/immunology
Male
Middle Aged
Molecular Sequence Data
Polymerase Chain Reaction
RNA, Messenger/metabolism
Tumor Necrosis Factor-alpha/genetics
Chemicals
Antigens, CD
Cytokines
Interleukin-1
Interleukin-2
Interleukin-6
RNA, Messenger
Tumor Necrosis Factor-alpha
Interleukin-4
Interferon-gamma
Alanine Transaminase
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Fukuda R
Second Department of Internal Medicine, Shimane Medical University, Japan.
Satoh S
Nguyen X T
Uchida Y
Kohge N
Akagi S
Ikeda S
Watanabe M
Fukumoto S
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