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PMID: 7726535 Published · ppublish English Journal Article

DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae.

Antimicrobial agents and chemotherapy ·Vol. 39 ·No. 2 ·1995-02-00 ·Pages 561-3

Deguchi T, Yasuda M, Asano M, Tada K, Iwata H, Komeda H, Ezaki T, Saito I, Kawada Y

Abstract

Eight quinolone-resistant clinical isolates of Neisseria gonorrhoeae were shown to carry mutations in their GyrA proteins. Six isolates had a single amino acid change of serine to phenylalanine at the position corresponding to Ser-83 in Escherichia coli. In addition to the change of serine to phenylalanine, two isolates had another change of aspartic acid to asparagine at the position corresponding to Asp-87 in E. coli.

MeSH Terms
Amino Acid Sequence Anti-Infective Agents/pharmacology Base Sequence DNA Gyrase DNA Topoisomerases, Type II/genetics Drug Resistance, Microbial Fluoroquinolones Molecular Sequence Data Mutation Neisseria gonorrhoeae/drug effects,enzymology
Chemicals
Anti-Infective Agents Fluoroquinolones DNA Gyrase DNA Topoisomerases, Type II
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Deguchi T
Department of Urology, Gifu University, Japan.
Yasuda M
Asano M
Tada K
Iwata H
Komeda H
Ezaki T
Saito I
Kawada Y
References (20)
20 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.39.2.561
Published
1995-02-00
Pages
561-3
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC162582
Subset
IM
Databases
GENBANK
D32252
External Links
PubMed source DOI: 10.1128/AAC.39.2.561 PMC Full Text View journal details
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