Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

Antimicrobial agents and chemotherapy ·Vol. 34 ·No. 6 ·1990-06-00 ·Pages 1271-2

Yoshida H, Bogaki M, Nakamura M, Nakamura S

Abstract

Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein.

MeSH Terms

4-Quinolones Anti-Infective Agents/pharmacology DNA Topoisomerases, Type II/genetics Drug Resistance, Microbial/genetics Escherichia coli/drug effects,genetics Mutation

Chemicals

4-Quinolones Anti-Infective Agents DNA Topoisomerases, Type II

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Yoshida H

Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.

Bogaki M

Nakamura M

Nakamura S

References (16)

16 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.34.6.1271

Published

1990-06-00

Pages

1271-2

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC171799

Subset

External Links

PubMed source DOI: 10.1128/AAC.34.6.1271 PMC Full Text View journal details

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Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

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