Evidence against autorepression of the betabeta' operon in Escherichia coli.

Molecular & general genetics : MGG ·Vol. 145 ·No. 2 ·1976-05-07 ·Pages 223-6

Tittawella IP

Abstract

By using rifampicin to increase the rate of beta and beta' synthesis in a heterodiploid strain of E. coli carrying the mutation rifpr (Km7), which codes for a rifampicin sensitive RNA polymerase to which the drug binds weakly, and the dominant mutation rifRD, which codes for a rifampicin resistant RNA polymerase, the concentration of these subunits in the cell was increased 1.6 fold. Measurements made after removal of rifampicin from the cells showed that the excess beta and beta' subunits did not reduce the rate of their own synthesis below normal.

MeSH Terms

DNA-Directed RNA Polymerases/metabolism Escherichia coli/drug effects Genes, Dominant Genes, Regulator Homeostasis Mutation Operon/drug effects Rifampin/pharmacology

Chemicals

DNA-Directed RNA Polymerases Rifampin

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Tittawella I P

References (17)

17 references, click to expand

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Article Info

Journal

Molecular & general genetics : MGG

Abbr.

Mol Gen Genet

ISSN

0026-8925

DOI

10.1007/BF00269598

Published

1976-05-07

Pages

223-6

Language

English

Region

Germany

NLM ID

0125036

Subset

External Links

PubMed source DOI: 10.1007/BF00269598

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Evidence against autorepression of the betabeta' operon in Escherichia coli.

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