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PMID: 786781 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Mapping of trichodermin resistance in Saccharomyces cerevisiae: a genetic locus for a component of the 60S ribsomal subunit.

Genetics ·Vol. 83 ·No. 4 ·1976-08-00 ·Pages 667-73

Grant PG, Schindler D, Davies JE

Abstract

Resistance to the protein synthesis inhibitor trichodermin in Saccharomyces cerevisiae has been studied. A single recessive nuclear gene was responsible for resistance. The resistance locus, tcm1 was found to be closely linked (1 centi-morgan) to the locus pet 17 on the right arm of chromosome XV. The mutation to trichodermin resistance conferred resistance to other 12,13-epoxytrichothecenes and to the structurally unrelated antibiotic anisomycin.

MeSH Terms
Anisomycin/pharmacology Chromosomes Drug Resistance, Microbial Genes, Recessive Genetic Linkage Mutation Saccharomyces cerevisiae/drug effects Sesquiterpenes/pharmacology Trichodermin/pharmacology
Chemicals
Sesquiterpenes Trichodermin Anisomycin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Grant P G
Schindler D
Davies J E
References (5)
5 references, click to expand
  1. Antibiotic inhibitors of the bacterial ribosome.
    Bacteriol Rev. 1968 Dec;32(4 Pt 2):493-528 PMID: 4179192
  2. Chromosome I as a possible site for some rRNA cistrons in Saccharomyces cerevisiae.
    FEBS Lett. 1973 Feb 15;30(1):53-56 PMID: 11947060
  3. Trichodermin resistance--mutation affecting eukaryotic ribosomes.
    Nature. 1974 Apr 5;248(448):535-6 PMID: 4596184
  4. New chromosomal location for structural genes of ribosomal proteins.
    Proc Natl Acad Sci U S A. 1975 Jul;72(7):2765-9 PMID: 1101266
  5. Modification of ribosomes in cryptopleurine-resistant mutants of yeast.
    J Bacteriol. 1973 Nov;116(2):818-22 PMID: 4583252
Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/83.4.667
Published
1976-08-00
Pages
667-73
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1213542
Subset
IM
External Links
PubMed source DOI: 10.1093/genetics/83.4.667 PMC Full Text View journal details
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