Home LiteratureArticle Details
PMID: 7933064 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Molecular biology of the human immunodeficiency virus accessory proteins.

Journal of virology ·Vol. 68 ·No. 11 ·1994-11-00 ·Pages 6831-5

Subbramanian RA, Cohen EA

Abstract

暂无摘要

MeSH Terms
Gene Products, nef/physiology Gene Products, vif/physiology Gene Products, vpr/physiology HIV-1/genetics Human Immunodeficiency Virus Proteins Viral Regulatory and Accessory Proteins/physiology nef Gene Products, Human Immunodeficiency Virus vif Gene Products, Human Immunodeficiency Virus vpr Gene Products, Human Immunodeficiency Virus
Chemicals
Gene Products, nef Gene Products, vif Gene Products, vpr Human Immunodeficiency Virus Proteins VPX protein, Human immunodeficiency virus 2 Viral Regulatory and Accessory Proteins nef Gene Products, Human Immunodeficiency Virus vif Gene Products, Human Immunodeficiency Virus vpr Gene Products, Human Immunodeficiency Virus vpu protein, Human immunodeficiency virus 1
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Subbramanian R A
Department of Microbiology and Immunology, Faculty of Medicine, University of Montreal, Quebec, Canada.
Cohen E A
References (67)
67 references, click to expand
  1. Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells.
    J Virol. 1993 Aug;67(8):4945-55 PMID: 8331734
  2. Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein.
    J Virol. 1993 Aug;67(8):5056-61 PMID: 8331740
  3. Identification of cellular proteins that bind to the human immunodeficiency virus type 1 nef gene product in vitro: a role for myristylation.
    J Gen Virol. 1993 Aug;74 ( Pt 8):1581-9 PMID: 8345349
  4. Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes.
    Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1539-43 PMID: 8108442
  5. Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3'-long terminal repeat transgene.
    J Exp Med. 1994 Mar 1;179(3):797-807 PMID: 8113676
  6. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain.
    Cell. 1994 Mar 11;76(5):853-64 PMID: 8124721
  7. Differential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartments.
    J Virol. 1994 Apr;68(4):2260-71 PMID: 8139011
  8. Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate.
    Virology. 1994 May 1;200(2):623-31 PMID: 8178448
  9. Role of vif during packing of the core of HIV-1.
    Virology. 1994 Jun;201(2):349-55 PMID: 8184544
  10. Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity.
    J Virol. 1994 Jun;68(6):3478-85 PMID: 8189487
  11. The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.
    Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7311-5 PMID: 8041786
  12. Polymorphism of the 3' open reading frame of the virus associated with the acquired immune deficiency syndrome, human T-lymphotropic virus type III.
    Nucleic Acids Res. 1985 Nov 25;13(22):8219-29 PMID: 2999715
  13. The HIV 'A' (sor) gene product is essential for virus infectivity.
    Nature. 1987 Aug 20-26;328(6132):728-30 PMID: 2441266
  14. The sor gene of HIV-1 is required for efficient virus transmission in vitro.
    Science. 1987 Aug 21;237(4817):888-93 PMID: 3497453
  15. HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product.
    Nature. 1987 Nov 19-25;330(6145):266-9 PMID: 3118220
  16. Isolation and characterization of a novel protein (X-ORF product) from SIV and HIV-2.
    Science. 1988 Jul 8;241(4862):199-201 PMID: 3388031
  17. Identification of a protein encoded by the vpu gene of HIV-1.
    Nature. 1988 Aug 11;334(6182):532-4 PMID: 3043230
  18. A novel gene of HIV-1, vpu, and its 16-kilodalton product.
    Science. 1988 Sep 2;241(4870):1221-3 PMID: 3261888
  19. Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR.
    Science. 1988 Sep 16;241(4872):1481-5 PMID: 3262235
  20. Human immunodeficiency virus type 1 negative factor is a transcriptional silencer.
    Proc Natl Acad Sci U S A. 1989 Feb;86(4):1128-32 PMID: 2784001
  21. Functional role of human immunodeficiency virus type 1 vpu.
    Proc Natl Acad Sci U S A. 1989 Jul;86(13):5163-7 PMID: 2472639
  22. Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu protein.
    J Virol. 1989 Sep;63(9):3784-91 PMID: 2788224
  23. Mutational analysis of the human immunodeficiency virus vpr open reading frame.
    J Virol. 1989 Sep;63(9):4110-4 PMID: 2474678
  24. Identification of HIV-1 vpr product and function.
    J Acquir Immune Defic Syndr. 1990;3(1):11-8 PMID: 2136707
  25. Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1.
    Proc Natl Acad Sci U S A. 1989 Dec;86(23):9544-8 PMID: 2687883
  26. Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor.
    Proc Natl Acad Sci U S A. 1989 Dec;86(23):9549-53 PMID: 2687884
  27. The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release.
    J Virol. 1990 Feb;64(2):621-9 PMID: 2404139
  28. Human immunodeficiency virus vpr product is a virion-associated regulatory protein.
    J Virol. 1990 Jun;64(6):3097-9 PMID: 2139896
  29. Origin of vpx in lentiviruses.
    Nature. 1990 Sep 27;347(6291):341-2 PMID: 2145513
  30. The human immunodeficiency virus type 2 vpr gene is essential for productive infection of human macrophages.
    Proc Natl Acad Sci U S A. 1990 Oct;87(20):8080-4 PMID: 2236020
  31. A specific inhibitor of cysteine proteases impairs a Vif-dependent modification of human immunodeficiency virus type 1 Env protein.
    J Virol. 1991 Mar;65(3):1325-31 PMID: 1995946
  32. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef.
    Nature. 1991 Apr 11;350(6318):508-11 PMID: 2014052
  33. Importance of the nef gene for maintenance of high virus loads and for development of AIDS.
    Cell. 1991 May 17;65(4):651-62 PMID: 2032289
  34. Human immunodeficiency virus type 2 vpx protein augments viral infectivity.
    Virology. 1991 Sep;184(1):197-209 PMID: 1714662
  35. Allelic variation in the effects of the nef gene on replication of human immunodeficiency virus type 1.
    Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10971-5 PMID: 1720558
  36. Human immunodeficiency virus type 1 Vpu protein regulates the formation of intracellular gp160-CD4 complexes.
    J Virol. 1992 Jan;66(1):226-34 PMID: 1727486
  37. Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes.
    Virology. 1992 May;188(1):391-5 PMID: 1566581
  38. The HIV-1 nef protein does not have guanine nucleotide binding, GTPase, or autophosphorylating activities.
    AIDS Res Hum Retroviruses. 1991 Dec;7(12):1015-20 PMID: 1812942
  39. Dual regulation of silent and productive infection in monocytes by distinct human immunodeficiency virus type 1 determinants.
    J Virol. 1992 Jun;66(6):3925-31 PMID: 1533883
  40. Envelope glycoprotein and CD4 independence of vpu-facilitated human immunodeficiency virus type 1 capsid export.
    J Virol. 1992 Aug;66(8):5119-26 PMID: 1629967
  41. In vivo derived HIV-1 nef gene products are heterogeneous and lack detectable nucleotide binding activity.
    AIDS Res Hum Retroviruses. 1992 May;8(5):537-43 PMID: 1515209
  42. Cell-free transmission of Vif mutants of HIV-1.
    Virology. 1992 Sep;190(1):19-29 PMID: 1529528
  43. Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes.
    J Virol. 1992 Nov;66(11):6489-95 PMID: 1357189
  44. Mechanism of action of regulatory proteins encoded by complex retroviruses.
    Microbiol Rev. 1992 Sep;56(3):375-94 PMID: 1406488
  45. Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4.
    J Virol. 1992 Dec;66(12):7193-200 PMID: 1433512
  46. Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus.
    J Virol. 1993 Feb;67(2):902-12 PMID: 8380472
  47. The effect of vpu on HIV-1-induced syncytia formation.
    J Acquir Immune Defic Syndr. 1993 Feb;6(2):135-41 PMID: 8094456
  48. Vpu protein of human immunodeficiency virus type 1 enhances the release of capsids produced by gag gene constructs of widely divergent retroviruses.
    Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7381-5 PMID: 8346259
  49. Human immunodeficiency virus type 1 Vpu protein induces degradation of chimeric envelope glycoproteins bearing the cytoplasmic and anchor domains of CD4: role of the cytoplasmic domain in Vpu-induced degradation in the endoplasmic reticulum.
    J Virol. 1993 Sep;67(9):5538-49 PMID: 8350411
  50. Efficiency of viral DNA synthesis during infection of permissive and nonpermissive cells with vif-negative human immunodeficiency virus type 1.
    J Virol. 1993 Oct;67(10):6322-6 PMID: 8371360
  51. Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions.
    J Virol. 1993 Nov;67(11):6542-50 PMID: 8411357
  52. Myristoylation-enhanced binding of the HIV-1 Nef protein to T cell skeletal matrix.
    Virology. 1993 Nov;197(1):420-5 PMID: 8212577
  53. Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of gag and mutational analysis.
    J Virol. 1993 Dec;67(12):7229-37 PMID: 8230445
  54. Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4.
    J Virol. 1993 Dec;67(12):7238-45 PMID: 8230446
  55. The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.
    J Exp Med. 1994 Jan 1;179(1):101-13 PMID: 8270859
  56. The human immunodeficiency virus type 1 (HIV-1) vif protein is located in the cytoplasm of infected cells and its effect on viral replication is equivalent in HIV-2.
    AIDS Res Hum Retroviruses. 1993 Oct;9(10):1025-30 PMID: 8280477
  57. Subcellular localization of the Vif protein of human immunodeficiency virus type 1.
    J Virol. 1994 Feb;68(2):704-12 PMID: 8289374
  58. The human immunodeficiency virus type 1 encoded Vpu protein is phosphorylated by casein kinase-2 (CK-2) at positions Ser52 and Ser56 within a predicted alpha-helix-turn-alpha-helix-motif.
    J Mol Biol. 1994 Feb 11;236(1):16-25 PMID: 8107101
  59. Cysteine residues in the Vif protein of human immunodeficiency virus type 1 are essential for viral infectivity.
    J Virol. 1994 Mar;68(3):1714-20 PMID: 8107232
  60. Requirement of the Pr55gag precursor for incorporation of the Vpr product into human immunodeficiency virus type 1 viral particles.
    J Virol. 1994 Mar;68(3):1926-34 PMID: 8107252
  61. The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4.
    J Virol. 1993 Mar;67(3):1511-6 PMID: 8437228
  62. Cell-dependent requirement of human immunodeficiency virus type 1 Vif protein for maturation of virus particles.
    J Virol. 1993 Mar;67(3):1663-6 PMID: 8437236
  63. Induction of cell differentiation by human immunodeficiency virus 1 vpr.
    Cell. 1993 Feb 26;72(4):541-50 PMID: 8440020
  64. Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene.
    EMBO J. 1993 Feb;12(2):703-13 PMID: 8095017
  65. Effect of nef alleles on replication of human immunodeficiency virus type 1.
    Virology. 1993 May;194(1):20-7 PMID: 7683154
  66. Human immunodeficiency virus type 1 Vpu protein induces degradation of CD4 in vitro: the cytoplasmic domain of CD4 contributes to Vpu sensitivity.
    J Virol. 1993 Jul;67(7):3877-84 PMID: 8510209
  67. Vpx of simian immunodeficiency virus is localized primarily outside the virus core in mature virions.
    J Virol. 1993 Jul;67(7):4386-90 PMID: 8510227
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.68.11.6831-6835.1994
Published
1994-11-00
Pages
6831-5
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC237118
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.68.11.6831-6835.1994 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2