The enteral insulin-stimulation after pancreas transplantation in the pig.

Diabetologia ·Vol. 12 ·No. 6 ·1976-12-00 ·Pages 617-20

Jensen SL, Nielsen OV, Kühl C

Abstract

The insulin responses to an oral glucose tolerance test (OGTT) and in intravenous glucose infusion (IVGI), designed to copy the changes in serum glucose concentrations found during OGTT, were measured in four pigs before and after heterotopic pancreatico-duodenal allotransplantation and total pancreatectomy. After transplantation and total pancreatectomy a remarkable hyperinsulinaemia occurred during OGTT and IVGI, reflected by an almost two-fold increment in the insulinogenic index after transplantation. This finding might be explained by drainage of the transplanted pancreas into the systemic circulation instead of the portal vein. The magnitude of the enteral stimulus, i. e. the incretin effect on insulin secretion during OGTT was unchanged after transplantation, suggesting that the incretin effect is not mediated by neural influences upon the endocrine pancreas.

MeSH Terms

Administration, Oral Animals Blood Glucose/analysis Glucose/administration & dosage Infusions, Parenteral Insulin/metabolism Insulin Secretion Pancreas/innervation Pancreas Transplantation Swine Transplantation, Homologous

Chemicals

Blood Glucose Insulin Glucose

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Jensen S L

Nielsen O V

Kühl C

References (26)

26 references, click to expand

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Article Info

Journal

Diabetologia

Abbr.

Diabetologia

ISSN

0012-186X

DOI

10.1007/BF01220640

Published

1976-12-00

Pages

617-20

Language

English

Region

Germany

NLM ID

0006777

Subset

External Links

PubMed source DOI: 10.1007/BF01220640 View journal details

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The enteral insulin-stimulation after pancreas transplantation in the pig.

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