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PMID: 7964974 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Tumoral invasion in the central nervous system.

Journal of neuro-oncology ·Vol. 18 ·No. 2 ·1994-00-00 ·Pages 111-21

De Clerck YA, Shimada H, Gonzalez-Gomez I, Raffel C

Abstract

During growth, migration and differentiation, cells closely interact with the extracellular matrix (ECM). The harmony between cells and their environment is a key factor that maintains the normal architecture of tissues. Loss of growth control is not the only characteristic of oncogenesis, loss of control by the ECM is an important event that allows malignant cells to further progress toward invasion and metastasis. Changes in cell adhesion, proteolytic degradation of the ECM and cell migration have all been described during invasion of most tissues by tumor cells. However little is known of these changes in tumors of the central nervous system (CNS). Although brain tumor cells may share some of the invasive characteristics of tumors that arise outside the CNS, the particular structure and composition of the brain ECM suggest the existence of unique invasive mechanisms in these tumors. Furthermore, the interaction between brain tumor cells and their ECM may explain the intriguing observation that despite their highly invasive behavior, these cells remain poorly metastatic. This review focuses on biochemical mechanisms essential for tumor invasion and how they relate to invasion of tumors that arise in the CNS.

MeSH Terms
Animals Brain Neoplasms/pathology Central Nervous System Neoplasms/pathology Extracellular Matrix/pathology Humans Neoplasm Invasiveness Neoplasm Metastasis
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
De Clerck Y A
Department of Pediatrics, Childrens Hospital Los Angeles, University of Southern California 90027.
Shimada H
Gonzalez-Gomez I
Raffel C
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Article Info
Journal
Journal of neuro-oncology
Abbr.
J Neurooncol
ISSN
0167-594X
DOI
10.1007/BF01050417
Published
1994-00-00
Pages
111-21
Language
English
Region
United States
NLM ID
8309335
Subset
IM
Grants
NCI NIH HHS · CA 42919 · United States
External Links
PubMed source DOI: 10.1007/BF01050417 View journal details
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