Home LiteratureArticle Details
PMID: 8031351 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Mycobacterium avium strains resistant to clarithromycin and azithromycin.

Antimicrobial agents and chemotherapy ·Vol. 37 ·No. 11 ·1993-11-00 ·Pages 2364-70

Heifets L, Mor N, Vanderkolk J

Abstract

Mycobacterium avium strains susceptible to clarithromycin and azithromycin contain mutants resistant to these macrolides with a frequency of 1.1 x 10(-10) to 1.2 x 10(-6). Cross-resistance between clarithromycin and azithromycin was demonstrated with mutants selected in the laboratory as well as with resistant strains isolated from patients. The susceptibility-resistance patterns of the macrolide-resistant strains with drugs other than macrolides were the same as those of the original susceptible strains. The emergence of clarithromycin resistance in patients was a result of multiplication of the preexisting resistant mutants that survived the elimination of bacteria during the initial period of treatment and was an exclusive cause of the relapse of bacteremia.

MeSH Terms
Azithromycin/pharmacology Clarithromycin/pharmacology Drug Resistance, Microbial Humans Microbial Sensitivity Tests Mycobacterium avium Complex/drug effects,metabolism Mycobacterium avium-intracellulare Infection/drug therapy,microbiology
Chemicals
Azithromycin Clarithromycin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Heifets L
National Jewish Center for Immunology, and Respiratory Medicine, University of Colorado Health Sciences Center, Denver.
Mor N
Vanderkolk J
References (17)
17 references, click to expand
  1. Azithromycin for treatment of Mycobacterium avium-intracellulare complex infection in patients with AIDS.
    Lancet. 1991 Nov 2;338(8775):1107-9 PMID: 1682544
  2. Effect of pH on the in vitro potency of clarithromycin against Mycobacterium avium complex.
    Antimicrob Agents Chemother. 1991 Aug;35(8):1677-8 PMID: 1834015
  3. The new macrolide antibiotics: azithromycin, clarithromycin, dirithromycin, and roxithromycin.
    Ann Pharmacother. 1992 Jan;26(1):46-55 PMID: 1318761
  4. Clarithromycin minimal inhibitory and bactericidal concentrations against Mycobacterium avium.
    Am Rev Respir Dis. 1992 Apr;145(4 Pt 1):856-8 PMID: 1532486
  5. Activities of clarithromycin against eight slowly growing species of nontuberculous mycobacteria, determined by using a broth microdilution MIC system.
    Antimicrob Agents Chemother. 1992 Sep;36(9):1987-90 PMID: 1416891
  6. Activity of clarithromycin against Mycobacterium avium complex infection in beige mice.
    Antimicrob Agents Chemother. 1992 Nov;36(11):2413-7 PMID: 1336945
  7. MICs and MBCs of clarithromycin against Mycobacterium avium within human macrophages.
    Antimicrob Agents Chemother. 1993 Jan;37(1):111-4 PMID: 8431006
  8. Development of streptomycin resistant strains of tubercle bacilli in pulmonary tuberculosis; results of simultaneous sensitivity tests in liquid and on solid media.
    Thorax. 1950 Jun;5(2):144-61 PMID: 15431218
  9. Comparison of the intracellular activities of clarithromycin and erythromycin against Mycobacterium avium complex strains in J774 cells and in alveolar macrophages from human immunodeficiency virus type 1-infected individuals.
    Antimicrob Agents Chemother. 1992 May;36(5):1163-5 PMID: 1387302
  10. Multiple drug resistance in Mycobacterium avium: is the wall architecture responsible for exclusion of antimicrobial agents?
    Antimicrob Agents Chemother. 1981 Nov;20(5):666-77 PMID: 6798925
  11. Comparative antimycobacterial activities of difloxacin, temafloxacin, enoxacin, pefloxacin, reference fluoroquinolones, and a new macrolide, clarithromycin.
    Antimicrob Agents Chemother. 1989 Apr;33(4):591-2 PMID: 2524998
  12. In vitro and in vivo activities of clarithromycin against Mycobacterium avium.
    Antimicrob Agents Chemother. 1989 Sep;33(9):1531-4 PMID: 2530933
  13. In vitro activities of several new macrolide antibiotics against Mycobacterium avium complex.
    Antimicrob Agents Chemother. 1989 Sep;33(9):1614-6 PMID: 2817858
  14. Activities of clarithromycin, sulfisoxazole, and rifabutin against Mycobacterium avium complex multiplication within human macrophages.
    Antimicrob Agents Chemother. 1990 Aug;34(8):1508-11 PMID: 2171421
  15. Extracellular and intracellular activities of clarithromycin used alone and in association with ethambutol and rifampin against Mycobacterium avium complex.
    Antimicrob Agents Chemother. 1991 Mar;35(3):462-70 PMID: 1828135
  16. Activity of clarithromycin against Mycobacterium avium infection in patients with the acquired immune deficiency syndrome. A controlled clinical trial.
    Am Rev Respir Dis. 1991 Sep;144(3 Pt 1):564-9 PMID: 1832527
  17. Activities of sparfloxacin, azithromycin, temafloxacin, and rifapentine compared with that of clarithromycin against multiplication of Mycobacterium avium complex within human macrophages.
    Antimicrob Agents Chemother. 1991 Jul;35(7):1356-9 PMID: 1656860
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.37.11.2364
Published
1993-11-00
Pages
2364-70
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC192393
Subset
IM
Corrections
CommentIn
PMID: 8031406
External Links
PubMed source DOI: 10.1128/AAC.37.11.2364 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2