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PMID: 806515 Published · ppublish English Journal Article

The adjuvant activity of a non-toxic, water-soluble glycopeptide present in large quantities in the culture filtrate of Mycobacterium tuberculosis strain DT.

Immunology ·Vol. 29 ·No. 1 ·1975-07-00 ·Pages 1-15

Stewart-Tull DE, Shimono T, Kotani S, Kato M, Ogawa Y, Yamamura Y, Koga T, Pearson CM

Abstract

A water-soluble mycobacterial glycopeptide was obtained in large quantities from the culture supernatant fluid of M. tuberculosis strain DT. This glycopeptide was strongly adjuvant-active when injected, in a water-in-oil emulsion contianing ovalbumin, into guinea-pigs. In addition, it was devoid of cord factor toxicity in mice, polyarthritogenic activity in rats and cavity stimulating activity in rabbit lungs.

MeSH Terms
Adjuvants, Immunologic Animals Arthritis/immunology Cord Factors/toxicity Cornea/immunology Glycopeptides/immunology Glycoproteins/toxicity Guinea Pigs/immunology Hypersensitivity, Delayed Immunoglobulin G/analysis Mycobacterium tuberculosis/immunology Ovalbumin/immunology Precipitin Tests Rabbits Rats Rats, Inbred Lew Skin Tests Solubility Tuberculosis, Pulmonary/immunology
Chemicals
Adjuvants, Immunologic Cord Factors Glycopeptides Glycoproteins Immunoglobulin G Ovalbumin
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Stewart-Tull D E
Shimono T
Kotani S
Kato M
Ogawa Y
Yamamura Y
Koga T
Pearson C M
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23 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1975-07-00
Pages
1-15
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1445873
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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