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PMID: 8118102 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Mapping the murine Xce locus with (CA)n repeats.

Mammalian genome : official journal of the International Mammalian Genome Society ·Vol. 4 ·No. 9 ·1993-09-00 ·Pages 523-30

Simmler MC, Cattanach BM, Rasberry C, Rougeulle C, Avner P

Abstract

The X Chromosome (Chr) controlling element locus (Xce) in the mouse has been shown to influence the X inactivation process. Xce maps to the central region of the X Chr, which also contains the Xist sequence, itself possibly implicated in the X inactivation process. Three microsatellite markers spanning the Xist locus have been isolated from an Xist containing YAC. All three microsatellite markers showed complete linkage with Xce in recombinants for the central span of the mouse X Chr between Ta and Moblo and strong linkage disequilibrium with Xce in all but one of the inbred mouse strains tested. In the standard Xceb typing strain JU/Ct, the two microsatellites most closely flanking Xist fail to carry the allelic forms expected if Xist and Xce are synonymous. Alternative explanations for this finding are presented in the context of our search for understanding the relation between Xist and Xce.

Related Genes
Xce Xist
MeSH Terms
Animals Base Sequence Chromosome Mapping Chromosomes, Artificial, Yeast DNA, Satellite Dosage Compensation, Genetic Genetic Markers Mice Mice, Inbred Strains Molecular Sequence Data Muridae Repetitive Sequences, Nucleic Acid X Chromosome
Chemicals
DNA, Satellite Genetic Markers
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Simmler M C
Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France.
Cattanach B M
Rasberry C
Rougeulle C
Avner P
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Article Info
Journal
Mammalian genome : official journal of the International Mammalian Genome Society
Abbr.
Mamm Genome
ISSN
0938-8990
DOI
10.1007/BF00364788
Published
1993-09-00
Pages
523-30
Language
English
Region
United States
NLM ID
9100916
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00364788 View journal details
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