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PMID: 8146136 Published · ppublish English Journal Article Review

Genital human papillomavirus infection.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 7 ·1994-03-29 ·Pages 2436-40

Lowy DR, Kirnbauer R, Schiller JT

Abstract

Genital human papillomavirus (HPV) infection is a common sexually transmitted disease that at the present time is not effectively controlled or treated. Many infections are inapparent and transient. However, some HPV infections result in persistent lesions that in some cases undergo carcinogenic progression. A subset of genital HPVs, designated high-risk types, are preferentially associated with high-grade dysplasias and carcinomas. About 90% of cervical cancers contain high-risk HPV DNA, most often HPV16. Development of a subunit vaccine against high-risk genital HPVs is a desirable and, it appears, an increasingly feasible long-term goal. The viral E6 and E7 oncoproteins are selectively maintained and expressed in progressed HPV tumors and could potentially be targets for therapeutic vaccines. The L1 major virion structural proteins have recently been shown to self-assemble into virus-like particles when expressed in insect cells. These particles might serve as the basis for a prophylactic vaccine to prevent genital HPV infection.

MeSH Terms
Antibodies, Viral/blood DNA, Viral/blood Female Humans Papillomaviridae/immunology,pathogenicity,ultrastructure Papillomavirus Infections/blood,prevention & control Tumor Virus Infections/blood,prevention & control Uterine Cervical Neoplasms/prevention & control,virology
Chemicals
Antibodies, Viral DNA, Viral
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lowy D R
Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892.
Kirnbauer R
Schiller J T
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.7.2436
Published
1994-03-29
Pages
2436-40
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC43385
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.91.7.2436 PMC Full Text View journal details
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