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PMID: 8146152 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Recombinational basis of serovar diversity in Salmonella enterica.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 7 ·1994-03-29 ·Pages 2552-6

Li J, Nelson K, McWhorter AC, Whittam TS, Selander RK

Abstract

The fliC gene, which encodes phase 1 flagellin, was sequenced in strains of 15 Salmonella enterica serovars expressing flagellar antigenic factors of the g series. The occurrence of each of the flagellin serotypes g,m, m,t, and g,z51 in distantly related strains is the result of horizontal exchange of DNA, as indicated by identity or close similarity in nucleotide sequence of all or parts of the antigenic factor-determining central region of fliC. The flagellin genes of some serovars are complex mosaic structures composed of diverse segments derived through multiple recombination events. Thus, recombination of horizontally transferred segments (intragenic) or entire genes (assortative) within and among subspecies is identified as a major evolutionary mechanism generating both allelic variation at the fliC locus and serovar diversity in natural populations. Evidence that flagellar serological diversity is promoted by diversifying selection in adaptation to host immune defense system or flagellotropic phage is discussed.

MeSH Terms
Base Sequence Biological Evolution Flagellin/chemistry,genetics Genes, Bacterial/genetics Genetic Variation Molecular Sequence Data Recombination, Genetic Salmonella/classification,genetics Sequence Analysis, DNA Sequence Homology, Nucleic Acid Serotyping
Chemicals
Flagellin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Li J
Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park 16802.
Nelson K
McWhorter A C
Whittam T S
Selander R K
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.7.2552
Published
1994-03-29
Pages
2552-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC43407
Subset
IM
Grants
NIAID NIH HHS · AI-22144 · United States
NIAID NIH HHS · AI-24566 · United States
Databases
GENBANK
M84974, U06197, U06198, U06199, U06200, U06201, U06202, U06203, U06204, U06205, U06206, U06225, U06226, U06227, U06455
External Links
PubMed source DOI: 10.1073/pnas.91.7.2552 PMC Full Text View journal details
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