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PMID: 815545 Published · ppublish English Journal Article

Potassium and calcium conductance in slow muscle fibres of the toad.

The Journal of physiology ·Vol. 255 ·No. 2 ·1976-02-00 ·Pages 435-48

Stefani E, Uchitel OD

Abstract

Slow muscle fibres in isotonic potassium sulphate saline could be easily repolarized to -90 mV. From this membrane potential a regenerative response could be elicited with short depolarizing pulses. 2. This response is blocked by TEA, suggesting that potassium is the main ion involved. 3. In the presence of TEA, a transient depolarization is recorded when the steady hyperpolarization is withdrawn. This anode break response is dependent upon the external calcium and is blocked by cobalt, suggesting that it is due to a calcium conductance. 4. The membrane conductance change was continuously recorded with short pulses at the end of the hyperpolarization. The membrane conductance decayed with at least two components with an average t1/2 of 1-2 and 6-8 sec. TEA blocked the slow component, and the fast one was dependent upon calcium and was blocked by cobalt.

MeSH Terms
Animals Bufo arenarum Calcium/metabolism Cobalt/pharmacology In Vitro Techniques Membrane Potentials/drug effects Muscles/metabolism Potassium/metabolism Regeneration Tetraethylammonium Compounds/pharmacology Tetrodotoxin/pharmacology Time Factors
Chemicals
Tetraethylammonium Compounds Cobalt Tetrodotoxin Potassium Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Stefani E
Uchitel O D
References (27)
27 references, click to expand
  1. Calcium and potassium systems of a giant barnacle muscle fibre under membrane potential control.
    J Physiol. 1973 Mar;229(2):409-55 PMID: 4724831
  2. Calcium entry in response to maintained depolarization of squid axons.
    J Physiol. 1973 Jun;231(3):527-48 PMID: 4783096
  3. Effects of manganese and other agents on the calcium uptake that follows depolarization of squid axons.
    J Physiol. 1973 Jun;231(3):511-26 PMID: 4783095
  4. Depolarization and calcium entry in squid giant axons.
    J Physiol. 1971 Nov;218(3):709-55 PMID: 5133953
  5. Force measurements in skinned muscle fibres.
    J Physiol. 1969 Feb;200(3):807-19 PMID: 5765859
  6. Tetrodotoxin-resistant electric activity in presynaptic terminals.
    J Physiol. 1969 Aug;203(2):459-87 PMID: 4307710
  7. Resting potential and electrical properties of frog slow muscle fibres. Effect of different external solutions.
    J Physiol. 1969 Aug;203(2):383-401 PMID: 5796469
  8. Calcium and potassium currents of the membrane of a barnacle muscle fibre in relation to the calcium spike.
    J Physiol. 1969 Nov;205(1):115-29 PMID: 5347712
  9. Transport and metabolism of calcium ions in nerve.
    Prog Biophys Mol Biol. 1972;24:177-223 PMID: 4118937
  10. Skeletal muscle: dependence of potassium contractures on extracellular calcium.
    Pflugers Arch. 1973 Oct 17;343(2):143-50 PMID: 4797850
  11. Selective inhibition of the transmembrane Ca conductivity of mammalian myocardial fibres by Ni, Co and Mn ions.
    Pflugers Arch. 1973 Jan 22;338(2):115-23 PMID: 4734652
  12. A convenient method for repeated intracellular recording of action potentials from the same muscle fibre without membrane damage.
    Pflugers Arch. 1972;334(3):276-8 PMID: 4676258
  13. Membrane calcium activation in excitation-contraction coupling.
    J Gen Physiol. 1972 Jun;59(6):676-88 PMID: 5025745
  14. Calcium ion and muscle contraction.
    Prog Biophys Mol Biol. 1968;18:123-83 PMID: 4894870
  15. Potassium conductance of skeletal muscle treated with formaldehyde.
    Nature. 1969 Dec 20;224(5225):1215-7 PMID: 5358348
  16. Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons.
    J Gen Physiol. 1969 Nov;54(5):553-75 PMID: 5346528
  17. The selective inhibition of delayed potassium currents in nerve by tetraethylammonium ion.
    J Gen Physiol. 1967 May;50(5):1287-302 PMID: 6033586
  18. Behavior of delayed current under voltage clamp in the supramedullary neurons of puffer.
    J Gen Physiol. 1966 Mar;49(4):613-28 PMID: 5943604
  19. Surface density of calcium ions and calcium spikes in the barnacle muscle fiber membrane.
    J Gen Physiol. 1967 Jan;50(3):583-601 PMID: 11526848
  20. THE ACTION OF CALCIUM IONS ON POTASSIUM CONTRACTURES OF SINGLE MUSCLE FIBRES.
    J Physiol. 1963 Oct;168:679-97 PMID: 14067951
  21. Ionic mechanisms in electrogenesis.
    Ann N Y Acad Sci. 1961 Sep 6;94:405-57 PMID: 13709244
  22. Excitation of the squid axon membrane in isosmotic potassium chloride.
    Nature. 1959 Jan 24;183(4656):265-6 PMID: 13622770
  23. The behaviour of frog muscle in hypertonic solutions.
    J Physiol. 1958 Nov 10;144(1):167-75 PMID: 13599116
  24. The role of calcium ions in neural processes.
    Pharmacol Rev. 1954 Sep;6(3):243-98 PMID: 13215068
  25. The effect of diameter on the electrical constants of frog skeletal muscle fibres.
    J Physiol. 1972 Feb;221(1):105-20 PMID: 4536963
  26. Intracellular calcium movements in skinned muscle fibres.
    J Physiol. 1972 May;223(1):21-33 PMID: 5046150
  27. Calcium inward currents in internally perfused giant axons.
    J Physiol. 1973 Nov;235(1):225-65 PMID: 4778139
Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1976.sp011288
Published
1976-02-00
Pages
435-48
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1309256
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1976.sp011288 PMC Full Text View journal details
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