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PMID: 8188388 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Tick transmission of Borrelia burgdorferi to inbred strains of mice induces an antibody response to P39 but not to outer surface protein A.

Infection and immunity ·Vol. 62 ·No. 6 ·1994-06-00 ·Pages 2625-7

Golde WT, Kappel KJ, Dequesne G, Feron C, Plainchamp D, Capiau C, Lobet Y

Abstract

Natural tick transmission of infection by Borrelia burgdorferi induces a very different serum antibody response than needle inoculation of spirochetes. We present data, obtained by using the mouse model, that show that the OspA response was barely detectable, whereas all animals developed significant anti-P39 titers after exposure to B. burgdorferi-infected ticks.

MeSH Terms
Animals Antibodies, Bacterial/biosynthesis Antigens, Bacterial/immunology Antigens, Surface/immunology Bacterial Outer Membrane Proteins/immunology Bacterial Vaccines Borrelia burgdorferi Group/immunology Lipoproteins Lyme Disease/immunology,transmission Mice Mice, Inbred BALB C Mice, Inbred C57BL Ticks/microbiology
Chemicals
Antibodies, Bacterial Antigens, Bacterial Antigens, Surface Bacterial Outer Membrane Proteins Bacterial Vaccines Lipoproteins OspA protein
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Golde W T
Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Fort Collins, Colorado 80522.
Kappel K J
Dequesne G
Feron C
Plainchamp D
Capiau C
Lobet Y
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.62.6.2625-2627.1994
Published
1994-06-00
Pages
2625-7
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC186556
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1128/iai.62.6.2625-2627.1994 PMC Full Text View journal details
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