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PMID: 8188390 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Diversity of the P2 protein among nontypeable Haemophilus influenzae isolates.

Infection and immunity ·Vol. 62 ·No. 6 ·1994-06-00 ·Pages 2639-43

Bell J, Grass S, Jeanteur D, Munson RS

Abstract

The genes for outer membrane protein P2 of four nontypeable Haemophilus influenzae strains were cloned and sequenced. The derived amino acid sequences were compared with the outer membrane protein P2 sequence from H. influenzae type b MinnA and the sequences of P2 from three additional nontypeable H. influenzae strains. The sequences were 76 to 94% identical. The sequences had regions with considerable variability separated by regions which were highly conserved. The variable regions mapped to putative surface-exposed loops of the protein.

MeSH Terms
Amino Acid Sequence Bacterial Outer Membrane Proteins/chemistry,genetics Cloning, Molecular DNA, Bacterial/chemistry Haemophilus influenzae/chemistry Molecular Sequence Data
Chemicals
Bacterial Outer Membrane Proteins DNA, Bacterial
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bell J
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Grass S
Jeanteur D
Munson R S
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.62.6.2639-2643.1994
Published
1994-06-00
Pages
2639-43
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC186559
Subset
IM
Grants
NIAID NIH HHS · R01-AI-17572 · United States
Databases
GENBANK
U08205, U08206, U08207, U08208
External Links
PubMed source DOI: 10.1128/iai.62.6.2639-2643.1994 PMC Full Text View journal details
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