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PMID: 819613 Published · ppublish English Journal Article

Genetic polymorphism of mouse immunoglobulin light chains revealed by isoelectric focusing.

The Journal of experimental medicine ·Vol. 144 ·No. 1 ·1976-07-01 ·Pages 298-303

Gibson D

Abstract

Light chains isolated from normal immunoglobulin of unimmunized mice were analyzed by gel isoelectric focusing. Examination of the focusing patterns of light chains from nine inbred mouse strains showed that six of the strains (SWR/J, C3H/HeJ, DBA/1J, A/J, CBA/J, and C57BL/6J) possessed a virtually identical spectrum of focusing bands, while the remaining three strains (RF/J, AKR/J, and C58/J) showed clear differences involving several bands. Analysis of the light chains of individual SWR/J, C58/J, and F1 hybrid mice indicated that the differences in focusing pattern were inherited in a simple codominant fashion. A new procedure was developed for the rapid analysis of light chains from small quantities of serum.

MeSH Terms
Animals Immunoglobulin Light Chains/analysis Isoelectric Focusing Mice Mice, Inbred Strains Polymorphism, Genetic
Chemicals
Immunoglobulin Light Chains
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Gibson D
References (12)
12 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.144.1.298
Published
1976-07-01
Pages
298-303
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2190346
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.144.1.298 PMC Full Text View journal details
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