Home LiteratureArticle Details
PMID: 8278411 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 1 ·1994-01-04 ·Pages 78-82

Miller DG, Edwards RH, Miller AD

Abstract

The host and tissue specificity of retrovirus infection is largely determined by specific cellular receptors that mediate virus entry. Genes encoding these receptors are widely distributed in the genome, and the receptors identified to date show no sequence similarity. We have identified the cellular receptor for amphotropic murine retroviruses, Ram-1, by screening a rat cDNA expression library introduced into amphotropic virus-resistant hamster cells. The 656-amino acid receptor is homologous to the gibbon ape leukemia virus receptor at both hydrophobic termini but is highly divergent in the central hydrophilic region. Both receptors appear to be integral membrane proteins having multiple membrane-spanning regions. Identification of this family of receptors will help define the evolutionary relationship between retroviruses and their cellular receptors.

Related Genes
Glvr-1 Ram-1
MeSH Terms
Amino Acid Sequence Chromosomes, Human, Pair 8 Cloning, Molecular Humans Leukemia Virus, Gibbon Ape/metabolism Molecular Sequence Data Phosphate Transport Proteins Receptors, Virus/chemistry,genetics Retroviridae/metabolism Sequence Alignment Sequence Homology, Amino Acid Sodium-Phosphate Cotransporter Proteins Sodium-Phosphate Cotransporter Proteins, Type III Symporters
Chemicals
Phosphate Transport Proteins Receptors, Virus Sodium-Phosphate Cotransporter Proteins Sodium-Phosphate Cotransporter Proteins, Type III Symporters leukemia virus receptor, gibbon ape
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Miller D G
Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
Edwards R H
Miller A D
References (30)
30 references, click to expand
  1. Nucleotide sequence of pho-4+, encoding a phosphate-repressible phosphate permease of Neurospora crassa.
    Gene. 1989 Nov 30;83(2):281-9 PMID: 2531109
  2. A recombinant retrovirus encoding alkaline phosphatase confirms clonal boundary assignment in lineage analysis of murine retina.
    Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):693-7 PMID: 1731342
  3. Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus.
    J Virol. 1992 Feb;66(2):1219-22 PMID: 1309898
  4. Tunicamycin treatment of CHO cells abrogates multiple blocks to retrovirus infection, one of which is due to a secreted inhibitor.
    J Virol. 1992 Jan;66(1):78-84 PMID: 1370096
  5. Molecular cloning and characterization of a novel human gene homologous to the murine ecotropic retroviral receptor.
    Virology. 1991 Nov;185(1):10-7 PMID: 1718082
  6. Localization of the amphotropic murine leukemia virus receptor gene to the pericentromeric region of human chromosome 8.
    J Virol. 1991 Nov;65(11):6316-9 PMID: 1656098
  7. Cell-surface receptor for ecotropic murine retroviruses is a basic amino-acid transporter.
    Nature. 1991 Aug 22;352(6337):729-31 PMID: 1908564
  8. Transport of cationic amino acids by the mouse ecotropic retrovirus receptor.
    Nature. 1991 Aug 22;352(6337):725-8 PMID: 1652100
  9. Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus.
    J Virol. 1991 May;65(5):2220-4 PMID: 1850008
  10. Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus.
    Cell Growth Differ. 1990 Mar;1(3):119-27 PMID: 2078500
  11. Localization of the human gene allowing infection by gibbon ape leukemia virus to human chromosome region 2q11-q14 and to the homologous region on mouse chromosome 2.
    J Virol. 1991 Apr;65(4):1743-7 PMID: 1672162
  12. Receptor interference groups of 20 retroviruses plating on human cells.
    Virology. 1990 May;176(1):58-69 PMID: 1691887
  13. Improved retroviral vectors for gene transfer and expression.
    Biotechniques. 1989 Oct;7(9):980-2, 984-6, 989-90 PMID: 2631796
  14. Sequence analysis of amphotropic and 10A1 murine leukemia viruses: close relationship to mink cell focus-inducing viruses.
    J Virol. 1990 Feb;64(2):757-66 PMID: 2153240
  15. Identification of mouse chromosomes required for murine leukemia virus replication.
    Cell. 1977 Aug;11(4):949-56 PMID: 196770
  16. Complementation between mutants of CHO cells resistant to a variety of plant lectins.
    Somatic Cell Genet. 1977 Jul;3(4):391-405 PMID: 601679
  17. Human gene therapy comes of age.
    Nature. 1992 Jun 11;357(6378):455-60 PMID: 1608446
  18. Inhibitors of retrovirus infection are secreted by several hamster cell lines and are also present in hamster sera.
    J Virol. 1993 Sep;67(9):5346-52 PMID: 8394452
  19. Isolation and characterization of a 2.3-kilobase-pair cDNA fragment encoding the binding domain of the bovine leukemia virus cell receptor.
    J Virol. 1993 Feb;67(2):1050-7 PMID: 8380453
  20. Gene transfer of a reserpine-sensitive mechanism of resistance to N-methyl-4-phenylpyridinium.
    Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9074-8 PMID: 1409604
  21. GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus.
    J Virol. 1992 Mar;66(3):1635-40 PMID: 1531369
  22. Receptor choice determinants in the envelope glycoproteins of amphotropic, xenotropic, and polytropic murine leukemia viruses.
    J Virol. 1992 Mar;66(3):1468-75 PMID: 1310758
  23. A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection.
    Cell. 1989 May 19;57(4):659-66 PMID: 2541919
  24. High-efficiency transformation of mammalian cells by plasmid DNA.
    Mol Cell Biol. 1987 Aug;7(8):2745-52 PMID: 3670292
  25. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain.
    Cell. 1986 Nov 7;47(3):333-48 PMID: 3094962
  26. The gene encoding the T-cell surface protein T4 is located on human chromosome 12.
    Proc Natl Acad Sci U S A. 1986 Jun;83(12):4399-402 PMID: 3086883
  27. Transformation of mammalian cells by avian myelocytomatosis virus and avian erythroblastosis virus.
    Virology. 1979 Oct 30;98(2):461-5 PMID: 228482
  28. A simple method for displaying the hydropathic character of a protein.
    J Mol Biol. 1982 May 5;157(1):105-32 PMID: 7108955
  29. Mechanism of galactosylation in the Golgi apparatus. A Chinese hamster ovary cell mutant deficient in translocation of UDP-galactose across Golgi vesicle membranes.
    J Biol Chem. 1986 Jan 5;261(1):96-100 PMID: 3510203
  30. Factors involved in production of helper virus-free retrovirus vectors.
    Somat Cell Mol Genet. 1986 Mar;12(2):175-83 PMID: 3457477
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.1.78
Published
1994-01-04
Pages
78-82
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC42889
Subset
IM
Databases
GENBANK
L19931
External Links
PubMed source DOI: 10.1073/pnas.91.1.78 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2