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PMID: 3086883 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The gene encoding the T-cell surface protein T4 is located on human chromosome 12.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 12 ·1986-06-00 ·Pages 4399-402

Isobe M, Huebner K, Maddon PJ, Littman DR, Axel R, Croce CM

Abstract

The surface glycoproteins T4 and T8 define functionally distinct populations of T lymphocytes. We have obtained cDNA and genomic clones encoding the T4 molecule and used these as probes to determine the chromosomal location of this gene. Genomic blotting experiments, along with in situ hybridization analyses, indicate that the T4 gene resides on the short arm of human chromosome 12, at region p12-pter. Thus, the T4 gene is not linked to any known member of the immunoglobulin gene family, including its counterpart gene, T8, which resides on human chromosome 2 immediately distal to the immunoglobulin kappa locus.

MeSH Terms
Antigens, Differentiation, T-Lymphocyte Antigens, Surface/genetics Chromosome Mapping Chromosomes, Human, 6-12 and X DNA/genetics Humans Hybrid Cells Membrane Proteins/genetics Nucleic Acid Hybridization Receptors, Virus/genetics T-Lymphocytes/physiology
Chemicals
Antigens, Differentiation, T-Lymphocyte Antigens, Surface Membrane Proteins Receptors, Virus DNA
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Isobe M
Huebner K
Maddon P J
Littman D R
Axel R
Croce C M
References (36)
36 references, click to expand
  1. Genetic correlation of a mouse light chain variable region marker with a thymocyte surface antigen.
    J Exp Med. 1974 Nov 1;140(5):1432-7 PMID: 4547628
  2. Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes.
    Science. 1984 Jul 6;225(4657):59-63 PMID: 6328660
  3. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.
    J Mol Biol. 1977 Jun 15;113(1):237-51 PMID: 881736
  4. Evidence for close linkage of a mouse light chain marker with the Ly-2,3 locus.
    J Immunol. 1978 Oct;121(4):1585-90 PMID: 100557
  5. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus.
    Nature. 1984 Dec 20-1985 Jan 2;312(5996):763-7 PMID: 6096719
  6. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV.
    Nature. 1984 Dec 20-1985 Jan 2;312(5996):767-8 PMID: 6083454
  7. Isolation of the gene encoding the human T-lymphocyte differentiation antigen Leu-2 (T8) by gene transfer and cDNA subtraction.
    Proc Natl Acad Sci U S A. 1984 Dec;81(24):7688-92 PMID: 6440142
  8. Preleukemia and leukemia with 12p- and 19q+ chromosome alterations following Alkeran therapy.
    Cancer Genet Cytogenet. 1985 Feb 1;15(1-2):95-8 PMID: 3967221
  9. The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes.
    Cell. 1985 Feb;40(2):237-46 PMID: 3871356
  10. The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions.
    Cell. 1985 Mar;40(3):591-7 PMID: 3918796
  11. Gene for the human T cell differentiation antigen Leu-2/T8 is closely linked to the kappa light chain locus on chromosome 2.
    J Exp Med. 1985 Feb 1;161(2):429-34 PMID: 3919142
  12. Chromosomal localization of three human ras genes by in situ molecular hybridization.
    Somat Cell Mol Genet. 1985 Mar;11(2):149-55 PMID: 3856955
  13. The alpha-spectrin gene is on chromosome 1 in mouse and man.
    Proc Natl Acad Sci U S A. 1985 Jun;82(11):3790-3 PMID: 2987946
  14. Regional mapping of cKi-ras proto-oncogene on mouse chromosome 6 by in situ hybridization.
    Cytogenet Cell Genet. 1985;39(2):140-4 PMID: 4006517
  15. The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.
    Cell. 1985 Aug;42(1):93-104 PMID: 2990730
  16. Chromosome localization of the gene for human terminal deoxynucleotidyltransferase to region 10q23-q25.
    Proc Natl Acad Sci U S A. 1985 Sep;82(17):5836-40 PMID: 3862101
  17. Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule.
    Science. 1986 Jan 24;231(4736):382-5 PMID: 3001934
  18. Extra chromosome 12 in chronic lymphocytic leukaemia.
    Lancet. 1980 Jan 19;1(8160):146-7 PMID: 6101473
  19. The differentiation and function of human T lymphocytes.
    Cell. 1980 Apr;19(4):821-7 PMID: 6991122
  20. Antibodies to membrane structures that distinguish suppressor/cytotoxic and helper T lymphocyte subpopulations block the mixed leukocyte reaction in man.
    J Exp Med. 1981 Jul 1;154(1):193-8 PMID: 6454755
  21. The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes.
    Nature. 1981 Aug 6;292(5823):506-11 PMID: 6265801
  22. Chromosomes and causation of human cancer and leukemia. XLV. Chromosome patterns in stimulated lymphocytes of chronic lymphocytic leukemia.
    Cancer Genet Cytogenet. 1981 Jun;3(4):293-306 PMID: 6266649
  23. Functional analysis of human T cell subsets defined by monoclonal antibodies. IV. Induction of suppressor cells within the OKT4+ population.
    J Exp Med. 1981 Aug 1;154(2):459-67 PMID: 6455486
  24. Selective inhibition of human T cell cytotoxicity at levels of target recognition or initiation of lysis by monoclonal OKT3 and Leu-2a antibodies.
    J Exp Med. 1982 May 1;155(5):1579-84 PMID: 6978378
  25. Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.
    Proc Natl Acad Sci U S A. 1982 Jul;79(14):4395-9 PMID: 6981813
  26. Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.
    Proc Natl Acad Sci U S A. 1982 Dec;79(24):7824-7 PMID: 6961453
  27. Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS).
    Science. 1983 May 20;220(4599):865-7 PMID: 6601823
  28. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).
    Science. 1983 May 20;220(4599):868-71 PMID: 6189183
  29. Chromosomal assignment of a family of human oncogenes.
    Proc Natl Acad Sci U S A. 1983 Jul;80(14):4460-3 PMID: 6576347
  30. Localization of c-ras oncogene family on human germ-line chromosomes.
    Proc Natl Acad Sci U S A. 1983 Aug;80(15):4794-7 PMID: 6308650
  31. T cell subsets and the recognition of MHC class.
    Immunol Rev. 1983;74:129-42 PMID: 6226585
  32. Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity.
    Immunol Rev. 1983;74:29-56 PMID: 6195085
  33. The T4 surface antigen is involved in the induction of helper function.
    J Immunol. 1984 Feb;132(2):735-9 PMID: 6228598
  34. New chromosomal translocations correlate with specific immunophenotypes of childhood acute lymphoblastic leukemia.
    Cell. 1984 Jan;36(1):101-9 PMID: 6607116
  35. Genomic sequencing.
    Proc Natl Acad Sci U S A. 1984 Apr;81(7):1991-5 PMID: 6326095
  36. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.12.4399
Published
1986-06-00
Pages
4399-402
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC323740
Subset
IM
Grants
NCI NIH HHS · CA-10815 · United States
NCI NIH HHS · CA-21124 · United States
NCI NIH HHS · CA-39860 · United States
External Links
PubMed source DOI: 10.1073/pnas.83.12.4399 PMC Full Text View journal details
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