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PMID: 3919142 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Gene for the human T cell differentiation antigen Leu-2/T8 is closely linked to the kappa light chain locus on chromosome 2.

The Journal of experimental medicine ·Vol. 161 ·No. 2 ·1985-02-01 ·Pages 429-34

Sukhatme VP, Vollmer AC, Erikson J, Isobe M, Croce C, Parnes JR

Abstract

We have mapped the gene encoding the T cell differentiation antigen Leu-2/T8 to human chromosome 2 by hybridization of a Leu-2/T8 complementary DNA clone to DNA from a panel of mouse-human cell hybrids. In situ hybridization further localizes the gene to the 2p1 region in close proximity to the Ig kappa light chain gene. The Leu-2/T8 gene translocates with C kappa to chromosome 8 in a Burkitt lymphoma line carrying a t(2;8) translocation. These data support the hypothesis that Leu-2/T8 is the human homologue of the mouse Lyt-2,3 antigen.

MeSH Terms
Animals Antigens, Differentiation, T-Lymphocyte Antigens, Surface/genetics Chromosomes, Human, 1-3 Cloning, Molecular DNA/genetics Genes, MHC Class II Genetic Code Genetic Linkage Humans Hybrid Cells Immunoglobulin Light Chains/genetics Immunoglobulin kappa-Chains/genetics Male Metaphase Mice
Chemicals
Antigens, Differentiation, T-Lymphocyte Antigens, Surface Immunoglobulin Light Chains Immunoglobulin kappa-Chains DNA
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Sukhatme V P
Vollmer A C
Erikson J
Isobe M
Croce C
Parnes J R
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22 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.161.2.429
Published
1985-02-01
Pages
429-34
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187568
Subset
IM
Grants
NIAID NIH HHS · AI-19512 · United States
External Links
PubMed source DOI: 10.1084/jem.161.2.429 PMC Full Text View journal details
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