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PMID: 831514 Published · ppublish English Comparative Study Journal Article

Further ultrastructural characterization of hairy cells of leukemic reticuloendotheliosis.

The American journal of pathology ·Vol. 86 ·No. 1 ·1977-01-00 ·Pages 163-82

Katayama I, Schneider GB

Abstract

Studies with transmission and scanning electron microscopes (TEM and SEM) were performed on specimens from patients suspected of leukemic reticuloendotheliosis (LRE), irrespective of the final diagnoses. The blood samples were fixed immediately in order to avoid in vitro changes of leukocytes. Leukemic reticuloendotheliosis cells demonstrated numerous long microvilli and pseudopods, whereas the immediately fixed lymphocytes demonstrated fewer, shorter microvilli and no pseudopods. These surface features distinguishing LRE cells from lymphocytes and monocytes were appreciated by both SEM and TEM. In addition, TEM revealed significant differences in the incidence of certain ultrastructural alterations. Whereas nuclear pockets were rare in lre cells, they were relatively frequent in lymphocytes of other hematologic disorders. The inclusions of ribosome-lamella complexes were not only more prevalent in patients with LRE but were seen in a higher percentage of leukemic cells from patients with LRE than in those from patients with other hematologic disorders. Electron microscopy can play a role in the laboratory diagnosis of LRE.

MeSH Terms
Bone Marrow/ultrastructure Bone Marrow Cells Cell Nucleus/ultrastructure Cytoplasm/ultrastructure Humans Leukemia/blood,pathology,ultrastructure Leukemia, Lymphoid/pathology Lymphatic Diseases/blood,ultrastructure Lymphocytes/ultrastructure Microscopy, Electron Microscopy, Electron, Scanning Monocytes/ultrastructure Ribosomes/ultrastructure Spleen/pathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Katayama I
Schneider G B
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47 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1977-01-00
Pages
163-82
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC2032052
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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