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PMID: 83303 Published · ppublish English Journal Article

Secretory immunoglobulin A and G antibodies prevent adhesion of Escherichia coli to human urinary tract epithelial cells.

Infection and immunity ·Vol. 22 ·No. 3 ·1978-12-00 ·Pages 790-7

Svanborg-Edén C, Svennerholm AM

Abstract

The adhesion of Escherichia coli to human urinary tract epithelial cells was inhibited by commercial gamma globulin, the total immunoglobulin fraction of human breast milk and urine, as well as the isolated immunoglobulin G and secretory immunoglobulin A fractions of urine from patients with acute pyelonephritis. Urinary anti-O6 antibodies reduced the adhesion of several O6 strains. Absorption of antibodies to the lipopolysaccharide of the adhering strain markedly decreased the antiadhesive capacity of all the immunoglobulin preparations, whereas elimination of antibodies to the capsular polysaccharide antigen consistently had a small but not significant effect. When urine was absorbed with whole, live bacteria of the patients' infecting strains, the antiadhesive effect completely disappeared. Absorption with bacteria lacking pili only partially reduced this effect.

MeSH Terms
Antibodies, Bacterial/urine Antigens, Bacterial Epithelial Cells Epithelium/microbiology Escherichia coli/immunology,physiology Humans Immunoglobulin A/urine Immunoglobulin A, Secretory/urine Immunoglobulin G/urine Milk, Human/immunology Polysaccharides, Bacterial/immunology Urinary Tract/cytology,microbiology gamma-Globulins
Chemicals
Antibodies, Bacterial Antigens, Bacterial Immunoglobulin A Immunoglobulin A, Secretory Immunoglobulin G Polysaccharides, Bacterial gamma-Globulins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Svanborg-Edén C
Svennerholm A M
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28 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.22.3.790-797.1978
Published
1978-12-00
Pages
790-7
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC422230
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.22.3.790-797.1978 PMC Full Text View journal details
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