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PMID: 8381351 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system.

The EMBO journal ·Vol. 12 ·No. 1 ·1993-01-00 ·Pages 307-14

Hamaguchi M, Matsuyoshi N, Ohnishi Y, Gotoh B, Takeichi M, Nagai Y

Abstract

Transformation of chick embryonic fibroblasts with Rous sarcoma virus strongly suppresses N-cadherin-mediated cell-cell adhesion, without inhibiting its expression. This suppression is correlated with tyrosine phosphorylation of N-cadherin and catenins, the cadherin-associated proteins, which are known to regulate cadherin function. Experiments with non-myristylation and temperature-sensitive mutants of RSV and with herbimycin A, a potent inhibitor of tyrosine kinases, suggest that both the suppression of cell adhesion and tyrosine phosphorylation of catenins are highly transformation-specific.

MeSH Terms
Animals Avian Sarcoma Viruses/genetics Benzoquinones Cadherins/physiology Cell Adhesion/physiology Cell Aggregation Cell Transformation, Neoplastic Cells, Cultured Chick Embryo Cytoskeletal Proteins/physiology Fibroblasts Lactams, Macrocyclic Methionine/metabolism Oncogene Protein pp60(v-src)/metabolism Phosphates/metabolism Phosphorylation Protein-Tyrosine Kinases/antagonists & inhibitors,metabolism Quinones/pharmacology Rifabutin/analogs & derivatives Tyrosine
Chemicals
Benzoquinones Cadherins Cytoskeletal Proteins Lactams, Macrocyclic Phosphates Quinones Rifabutin Tyrosine herbimycin Methionine Protein-Tyrosine Kinases Oncogene Protein pp60(v-src)
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Hamaguchi M
Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan.
Matsuyoshi N
Ohnishi Y
Gotoh B
Takeichi M
Nagai Y
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1993-01-00
Pages
307-14
Language
English
Region
England
NLM ID
8208664
PMCID
PMC413207
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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