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PMID: 8391108 Published · ppublish English Comparative Study Journal Article

emb-5, a gene required for the correct timing of gut precursor cell division during gastrulation in Caenorhabditis elegans, encodes a protein similar to the yeast nuclear protein SPT6.

Molecular & general genetics : MGG ·Vol. 239 ·No. 3 ·1993-06-00 ·Pages 313-22

Nishiwaki K, Sano T, Miwa J

Abstract

The emb-5 gene is required for the correct timing of division of gut precursor cells during gastrulation in Caenorhabditis elegans. We have now characterized the molecular structure of emb-5. The predicted emb-5-encoded protein (EMB-5) possesses an extremely acidic amino-terminus and overall similarity to the Saccharomyces cerevisiae nuclear protein SPT6, which has been shown to affect the transcription of a variety of genes and suggested to play a role in chromatin assembly or modification. EMB-5 may function in the control of cell cycle timing by modulating chromatin structure and consequently affects morphogenesis of C. elegans.

Related Genes
emb-5
MeSH Terms
Amino Acid Sequence Animals Base Sequence Caenorhabditis elegans/embryology,genetics Cell Division/genetics Chromosome Mapping Chromosome Walking DNA Mutational Analysis DNA Transposable Elements Female Fungal Proteins/genetics Gastrula/cytology Genes, Fungal Genes, Helminth Helminth Proteins/chemistry,genetics Histone Chaperones Intestines/embryology Male Molecular Sequence Data Morphogenesis Nuclear Proteins/genetics Saccharomyces cerevisiae/genetics Saccharomyces cerevisiae Proteins Transcription Factors/chemistry,genetics Transcriptional Elongation Factors Transformation, Genetic
Chemicals
DNA Transposable Elements Fungal Proteins Helminth Proteins Histone Chaperones Nuclear Proteins SPT6 protein, S cerevisiae Saccharomyces cerevisiae Proteins Transcription Factors Transcriptional Elongation Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Nishiwaki K
Fundamental Research Laboratories, NEC Corporation, Tsukuba, Japan.
Sano T
Miwa J
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00276929
Published
1993-06-00
Pages
313-22
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
Databases
GENBANK
D14635
External Links
PubMed source DOI: 10.1007/BF00276929
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