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PMID: 8494376 Published · ppublish English Journal Article

Antimicrobial susceptibility of Pediococcus spp. and genetic basis of macrolide resistance in Pediococcus acidilactici HM3020.

Antimicrobial agents and chemotherapy ·Vol. 37 ·No. 4 ·1993-04-00 ·Pages 789-92

Tankovic J, Leclercq R, Duval J

Abstract

We determined the MICs of 28 antimicrobial agents against 36 clinical strains of Pediococcus spp. (25 P. acidilactici, 9 P. pentosaceus, and 2 P. urinaeequi strains). Penicillin G, imipenem, gentamicin, netilmicin, erythromycin, clindamycin, rifampin, chloramphenicol, daptomycin, and ramoplanin were the most active. All strains of P. acidilactici were susceptible to novobiocin, whereas all isolates of P. pentosaceus were resistant. Novobiocin could therefore be helpful for differentiation of these two closely related species. P. acidilactici HM3020 was inducibly resistant to macrolide, lincosamide, and streptogramin B-type (MLS) antibiotics. Resistance was due to a determinant homologous to ermAM and carried by a nontransferable 46-kb plasmid, pVM20. This plasmid was structurally distinct from two enterococcal MLS resistance plasmids, pIP819 and pAM beta 1. The 34 strains of P. acidilactici and P. pentosaceus were resistant to tetracycline, and total DNA of these strains did not hybridize to probes specific for tetK, tetL, tetM, and tetO.

Related Genes
tet
MeSH Terms
Anti-Bacterial Agents/pharmacology DNA Probes DNA, Bacterial/isolation & purification,metabolism Drug Resistance, Microbial Erythromycin/pharmacology Microbial Sensitivity Tests Nucleic Acid Hybridization Pediococcus/drug effects,genetics Plasmids
Chemicals
Anti-Bacterial Agents DNA Probes DNA, Bacterial Erythromycin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tankovic J
Servíce de Bactériologie-Virologie-Hygiène, Hôpital Henri Mondor, Université Paris XII, Créteil, France.
Leclercq R
Duval J
References (33)
33 references, click to expand
  1. Vancomycin-resistant gram-positive bacteria isolated from human sources.
    J Clin Microbiol. 1988 Oct;26(10):2064-8 PMID: 3182995
  2. Nucleotide sequence of ermA, a macrolide-lincosamide-streptogramin B determinant in Staphylococcus aureus.
    J Bacteriol. 1985 May;162(2):633-40 PMID: 2985541
  3. Clinical laboratory challenges in the recognition of Leuconostoc spp.
    J Clin Microbiol. 1988 Mar;26(3):479-83 PMID: 3128577
  4. Molecular analysis of a composite chromosomal conjugative element (Tn3701) of Streptococcus pyogenes.
    J Bacteriol. 1988 Sep;170(9):3930-6 PMID: 2842292
  5. The isolation of pediococci from human saliva.
    Arch Oral Biol. 1966 Oct;11(10):967-72 PMID: 5226785
  6. Nucleotide sequence of the tetM tetracycline resistance determinant of the streptococcal conjugative shuttle transposon Tn1545.
    Nucleic Acids Res. 1986 Sep 11;14(17):7047-58 PMID: 3020504
  7. Evolution and spread of tetracycline resistance determinants.
    J Antimicrob Chemother. 1989 Jul;24(1):1-3 PMID: 2674098
  8. In vitro activity of 43 antimicrobial agents tested against ampicillin-resistant enterococci and gram-positive species resistant to vancomycin.
    Diagn Microbiol Infect Dis. 1991 Jul-Aug;14(4):337-45 PMID: 1889183
  9. Pediococci and biotechnology.
    Crit Rev Microbiol. 1987;14(4):291-309 PMID: 3308317
  10. Identification of gram-positive coccal and coccobacillary vancomycin-resistant bacteria.
    J Clin Microbiol. 1989 Apr;27(4):724-30 PMID: 2723037
  11. Properties of erythromycin-inducible transposon Tn917 in Streptococcus faecalis.
    J Bacteriol. 1980 Mar;141(3):1366-74 PMID: 6245068
  12. Genetic basis of antibiotic resistance in Aerococcus viridans.
    Antimicrob Agents Chemother. 1989 Apr;33(4):529-34 PMID: 2729946
  13. Clinical and microbiologic characteristics of pediococci.
    J Clin Microbiol. 1990 Jun;28(6):1348-55 PMID: 2380362
  14. Elimination of plasmids from several bacterial species by novobiocin.
    Antimicrob Agents Chemother. 1977 Sep;12(3):423-6 PMID: 907332
  15. Vancomycin-resistant Pediococcus acidilactici: nine cases of bacteremia.
    J Infect Dis. 1990 May;161(5):956-60 PMID: 2324545
  16. Vancomycin-resistant leuconostocs, lactobacilli and now pediococci.
    J Hosp Infect. 1987 Jul;10(1):1-3 PMID: 2888805
  17. Characterization of three plasmid deoxyribonucleic acid molecules in a strain of Streptococcus faecalis: identification of a plasmid determining erythromycin resistance.
    J Bacteriol. 1974 Jan;117(1):283-9 PMID: 4202995
  18. Gene heterogeneity for resistance to macrolides, lincosamides and streptogramins in Enterobacteriaceae.
    Ann Inst Pasteur Microbiol. 1988 Nov-Dec;139(6):677-81 PMID: 3150940
  19. Resistance to vancomycin and teicoplanin: an emerging clinical problem.
    Clin Microbiol Rev. 1990 Jul;3(3):280-91 PMID: 2143434
  20. Nucleotide sequence of the tetracycline resistance gene of pTHT15, a thermophilic Bacillus plasmid: comparison with staphylococcal TcR controls.
    Gene. 1985;37(1-3):131-8 PMID: 2996983
  21. Antimicrobial susceptibility of vancomycin-resistant Leuconostoc, Pediococcus, and Lactobacillus species.
    Antimicrob Agents Chemother. 1990 Apr;34(4):543-9 PMID: 2344161
  22. Bacterial resistance to macrolide, lincosamide, and streptogramin antibiotics by target modification.
    Antimicrob Agents Chemother. 1991 Jul;35(7):1267-72 PMID: 1929280
  23. Conjugative plasmid transfer from Enterococcus faecalis to Escherichia coli.
    J Bacteriol. 1988 Sep;170(9):4388-91 PMID: 3137216
  24. Identification and cloning of a plasmid-encoded erythromycin resistance determinant from Lactobacillus reuteri.
    Plasmid. 1988 Sep;20(2):171-4 PMID: 3237864
  25. Septicemia caused by vancomycin-resistant Pediococcus acidilactici.
    J Clin Microbiol. 1990 Jul;28(7):1678-9 PMID: 2199529
  26. Transferable vancomycin and teicoplanin resistance in Enterococcus faecium.
    Antimicrob Agents Chemother. 1989 Jan;33(1):10-5 PMID: 2523687
  27. Complete nucleotide sequence of pT181, a tetracycline-resistance plasmid from Staphylococcus aureus.
    Plasmid. 1983 Nov;10(3):251-9 PMID: 6657777
  28. Transposable multiple antibiotic resistance in Streptococcus pneumoniae.
    Mol Gen Genet. 1986 Nov;205(2):291-7 PMID: 3027505
  29. Septicaemia caused by Pediococcus pentosaceus: a new opportunistic pathogen.
    J Infect. 1991 Sep;23(2):179-82 PMID: 1753117
  30. THE DETECTION OF PENICILLINASE-PRODUCING PROPERTIES OF MICROORGANISMS.
    Science. 1945 Sep 21;102(2647):309 PMID: 17829682
  31. Plasmid transfer in Pediococcus spp.: intergeneric and intrageneric transfer of pIP501.
    Appl Environ Microbiol. 1983 Jul;46(1):81-9 PMID: 6311098
  32. Infection due to Leuconostoc species: six cases and review.
    Rev Infect Dis. 1990 Jul-Aug;12(4):602-10 PMID: 2201065
  33. Medium-dependent zone size discrepancies associated with susceptibility testing of group D streptococci against various cephalosporins.
    J Clin Microbiol. 1983 Oct;18(4):858-65 PMID: 6415100
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.37.4.789
Published
1993-04-00
Pages
789-92
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC187762
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.37.4.789 PMC Full Text View journal details
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