A second case of human C3b inhibitor (KAF) deficiency.

Clinical and experimental immunology ·Vol. 27 ·No. 1 ·1977-01-00 ·Pages 23-9

Thompson RA, Lachmann PJ

Abstract

The second case of C3b inhibitor deficiency is described in an 11-year-old girl who presented with recurrent attacks of meningitis, in between which she was well. Her serum showed all of the complement component changes noted in the first described case, although showing only a relatively slight defect in its ability to opsonize bacteria for phagocytosis and killing by polymorphonuclear leucocytes. This correlated with the patient's freedom from other infections.

MeSH Terms

Chemotaxis, Leukocyte Child Complement C3/antagonists & inhibitors,deficiency Complement System Proteins/deficiency,metabolism Enzyme Inhibitors/pharmacology Female Humans Meningitis/immunology Recurrence Serum Globulins/pharmacology

Chemicals

Complement C3 Enzyme Inhibitors Serum Globulins Complement System Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Thompson R A

Lachmann P J

References (15)

15 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1977-01-00

Pages

23-9

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1540911

Subset

External Links

PubMed source PMC Full Text View journal details

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A second case of human C3b inhibitor (KAF) deficiency.

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