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PMID: 8528584 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Loss of telomeric sites in the chromosomes of Mus musculus domesticus (Rodentia: Muridae) during Robertsonian rearrangements.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology ·Vol. 3 ·No. 7 ·1995-11-00 ·Pages 399-409

Nanda I, Schneider-Rasp S, Winking H, Schmid M

Abstract

Mouse chromosomes possessing multiple Robertsonian rearrangements (Rb chromosomes) have been examined using fluorescence in situ hybridization with the telomeric consensus sequence (TTAGGG)n. No hybridization signals were detected at the primary constriction of Rb chromosomes. This observation leads us to conclude that the formation of Rb chromosomes in the mouse is invariably associated with the loss of telomeric regions. More significantly, a further alteration in regions flanking the primary constrictions was observed after hybridizing with a minor satellite DNA probe to Rb chromosomes. It seems likely that the breakpoints required for a Robertsonian process do not include telomeric sites exclusively but extend to the adjacent pericentromeric regions of the original acrocentric chromosomes. In contrast to previous reports, these observations demonstrate the elimination of substantial amounts of chromosomal DNA during the formation of mouse Rb chromosomes.

MeSH Terms
Animals Chromosome Aberrations Chromosome Banding Chromosome Deletion Chromosomes/genetics,ultrastructure Consensus Sequence/genetics DNA/analysis DNA Probes DNA, Satellite/genetics In Situ Hybridization, Fluorescence Karyotyping Mice/genetics Repetitive Sequences, Nucleic Acid/genetics Telomere/genetics Y Chromosome/genetics
Chemicals
DNA Probes DNA, Satellite DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Nanda I
Department of Human Genetics, University of Würzburg, Germany.
Schneider-Rasp S
Winking H
Schmid M
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Article Info
Journal
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
Abbr.
Chromosome Res
ISSN
0967-3849
DOI
10.1007/BF00713889
Published
1995-11-00
Pages
399-409
Language
English
Region
Netherlands
NLM ID
9313452
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00713889 View journal details
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