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PMID: 8529274 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

RAD58 (XRS4)--a new gene in the RAD52 epistasis group.

Current genetics ·Vol. 28 ·No. 3 ·1995-08-00 ·Pages 274-9

Chepurnaya OV, Kozhin SA, Peshekhonov VT, Korolev VG

Abstract

The RAD58 (XRS4) gene of Saccharomyces cerevisiae has been previously identified as a DNA repair gene. In this communication, we show that RAD58 also encodes an essential meiotic function. The spore inviability of rad58 strains is not rescued by a spo13 mutation. The rad50 mutation suppresses spore inviability of a spo13 rad58 strain suggesting that RAD58 acts after RAD50 in meiotic recombination. The rad58-4 mutation does not prevent mitotic recombination events. Haploid rad58 cells fail to carry out G2-repair of gamma-induced lesions, whereas rad58/rad58 diploids are able to perform some diploid-specific repair of these lesions.

MeSH Terms
DNA Damage DNA Repair DNA, Fungal/genetics,metabolism,radiation effects Epistasis, Genetic Fungal Proteins/genetics,physiology Gamma Rays Genes, Fungal Genetic Complementation Test Meiosis Plasmids/genetics Ploidies Recombination, Genetic Reproduction Saccharomyces cerevisiae/genetics,metabolism Saccharomyces cerevisiae Proteins
Chemicals
DNA, Fungal Fungal Proteins SPO13 protein, S cerevisiae Saccharomyces cerevisiae Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Chepurnaya O V
Department of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute Academy of Sciences of Russia, Gatchina, Russia.
Kozhin S A
Peshekhonov V T
Korolev V G
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Article Info
Journal
Current genetics
Abbr.
Curr Genet
ISSN
0172-8083
DOI
10.1007/BF00309787
Published
1995-08-00
Pages
274-9
Language
English
Region
United States
NLM ID
8004904
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00309787 View journal details
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