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PMID: 8574854 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor.

Immunity ·Vol. 4 ·No. 1 ·1996-01-00 ·Pages 77-85

Burshtyn DN, Scharenberg AM, Wagtmann N, Rajagopalan S, Berrada K, Yi T, Kinet JP, Long EO

Abstract

Cytolysis of target cells by natural killer (NK) cells and by some cytotoxic T cells occurs unless prevented by inhibitory receptors that recognize MHC class I on target cells. Human NK cells express a p58 inhibitory receptor specific for HLA-C. We report association of the tyrosine phosphatase HCP with the p58 receptor in NK cells. HCP association was dependent on tyrosine phosphorylation of p58. Phosphotyrosyl peptides corresponding to the p58 tail bound and activated HCP in vitro. Furthermore, introduction of an inactive mutant HCP into an NK cell line prevented the p58-mediated inhibition of target cell lysis. These data imply that the inhibitory function of p58 is dependent on its tyrosine phosphorylation and on recruitment and activation of HCP.

MeSH Terms
Amino Acid Sequence Cell Line Cytotoxicity, Immunologic HLA-C Antigens/immunology,metabolism Humans Killer Cells, Natural/immunology,metabolism Molecular Sequence Data Mutation Protein Tyrosine Phosphatases/genetics,immunology Receptors, Cytoplasmic and Nuclear/immunology Receptors, Immunologic/immunology
Chemicals
HLA-C Antigens Receptors, Cytoplasmic and Nuclear Receptors, Immunologic lamin B receptor Protein Tyrosine Phosphatases
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Burshtyn D N
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA.
Scharenberg A M
Wagtmann N
Rajagopalan S
Berrada K
Yi T
Kinet J P
Long E O
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Article Info
Journal
Immunity
Abbr.
Immunity
ISSN
1074-7613
DOI
10.1016/s1074-7613(00)80300-3
Published
1996-01-00
Pages
77-85
Language
English
Region
United States
NLM ID
9432918
PMCID
PMC2423819
Subset
IM
Grants
Intramural NIH HHS · Z01 AI000525-20 · United States
Corrections
CommentIn
PMID: 24058191
External Links
PubMed source DOI: 10.1016/s1074-7613(00)80300-3 PMC Full Text View journal details
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