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PMID: 8606123 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Binding between outer membrane proteins of nontypeable Haemophilus influenzae and human nasopharyngeal mucin.

Infection and immunity ·Vol. 64 ·No. 4 ·1996-04-00 ·Pages 1477-9

Reddy MS, Bernstein JM, Murphy TF, Faden HS

Abstract

Bacterial colonization of the epithelial cells precedes infection. Mucins of the epithelial cell secretions modulate bacterial colonization. This study was designed to understand the mechanism of mucin-bacterial interactions and in particular binding between nontypeable Haemophilus influenzae and nasopharyngeal mucin(s). In an overlay assay, binding appears to be mediated by outer membrane proteins P2 and P5 of bacteria and sialic acid-containing oligosaccharides of mucin.

MeSH Terms
Bacterial Outer Membrane Proteins/metabolism Child Child, Preschool Haemophilus influenzae/physiology Humans Mucins/metabolism Nasopharynx/microbiology
Chemicals
Bacterial Outer Membrane Proteins Mucins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Reddy M S
Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, New York, USA.
Bernstein J M
Murphy T F
Faden H S
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.64.4.1477-1479.1996
Published
1996-04-00
Pages
1477-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC173948
Subset
IM
Grants
PHS HHS · 19679 · United States
NIAID NIH HHS · AI19641 · United States
NIDCR NIH HHS · DE11064 · United States
External Links
PubMed source DOI: 10.1128/iai.64.4.1477-1479.1996 PMC Full Text View journal details
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