Assignment of the human ST2 gene to chromosome 2 at q11.2.

Human genetics ·Vol. 97 ·No. 5 ·1996-05-00 ·Pages 561-3

Tominaga S, Inazawa J, Tsuji S

Abstract

The human St2 locus has been assigned to chromosome 2, using a human ST2 cDNA clone, by a human/rodent somatic cel hybrid mapping panel. The St2 locus has also been mapped to chromosome 2q11.2, using a human ST2 genomic DNA clone, by in situ hybridization. The locus is very tightly linked to the Il-1r1 locus. Together with the structural similarity of ST2 to IL-1RI, these data suggest functional relationships between these two genes.

MeSH Terms

Animals CHO Cells Chromosome Mapping Cloning, Molecular Cricetinae Humans Hybrid Cells In Situ Hybridization, Fluorescence Interleukin-1 Receptor-Like 1 Protein Membrane Proteins Protein Biosynthesis Proteins/genetics Receptors, Cell Surface Recombinant Proteins/biosynthesis Rodentia

Chemicals

IL1RL1 protein, human Interleukin-1 Receptor-Like 1 Protein Membrane Proteins Proteins Receptors, Cell Surface Recombinant Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Tominaga S

Department of Biochemistry II, Jichi Medical School, Tochigi, Japan.

Inazawa J

Tsuji S

References (7)

7 references, click to expand

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Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping.
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High-resolution cytogenetic mapping of 342 new cosmid markers including 43 RFLP markers on human chromosome 17 by fluorescence in situ hybridization.
Genomics. 1993 Jul;17(1):153-62 PMID: 8104866
Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1.
FEBS Lett. 1993 Feb 22;318(1):83-7 PMID: 7916701
A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor.
FEBS Lett. 1989 Dec 4;258(2):301-4 PMID: 2532153
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
Anal Biochem. 1983 Jul 1;132(1):6-13 PMID: 6312838
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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF02281860

Published

1996-05-00

Pages

561-3

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF02281860 View journal details

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Assignment of the human ST2 gene to chromosome 2 at q11.2.

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