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PMID: 8738606 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Mammary tumors induced by human adenovirus type 9: a role for the viral early region 4 gene.

Breast cancer research and treatment ·Vol. 39 ·No. 1 ·1996-00-00 ·Pages 57-67

Javier R, Shenk T

Abstract

Human adenovirus type 9 (Ad9) elicits exclusively estrogen-dependent mammary tumors when injected into female rats. Three different histological types of mammary tumor (benign fibroadenomas, phyllodes tumors, and malignant solid sarcomas) have been described in Ad9-infected animals, with benign fibroadenomas being seen most frequently. Interestingly, in contrast to other adenoviruses, in which oncogenic viral functions are entirely encoded within the E1 region, Ad9 requires an E4 region transforming protein (ORF1) for its unique mammary oncogenicity. Studies of Ad9-induced rat mammary tumors may lead to a detailed molecular understanding for the development of fibroadenoma, a common human breast tumor.

MeSH Terms
Adenoviruses, Human/chemistry,genetics Animals Base Sequence DNA, Viral/metabolism Estrogens/physiology Female Fibroadenoma/pathology,virology Gene Expression Regulation, Viral Male Mammary Neoplasms, Experimental/metabolism,pathology,virology Molecular Sequence Data Oncogene Proteins, Viral/chemistry,genetics,physiology RNA, Messenger/metabolism Rats Rats, Wistar
Chemicals
DNA, Viral E4 protein, Adenovirus 9 Estrogens Oncogene Proteins, Viral RNA, Messenger
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Javier R
Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA.
Shenk T
References (39)
39 references, click to expand
  1. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein.
    Nature. 1992 May 7;357(6373):82-5 PMID: 1533443
  2. Transcriptional and transforming activities of the adenovirus E1A proteins.
    Adv Cancer Res. 1991;57:47-85 PMID: 1835254
  3. Cytogenetic and fluorescence in situ hybridization analysis of breast fibroadenomas.
    Cancer Genet Cytogenet. 1992 Oct 1;63(1):32-6 PMID: 1423223
  4. The quest for human cancer viruses.
    Science. 1962 Sep 14;137(3533):835-41 PMID: 13922417
  5. Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells.
    Cell. 1982 Feb;28(2):387-94 PMID: 6277513
  6. Presence of a potent transcription activating sequence in the p53 protein.
    Science. 1990 Aug 31;249(4972):1046-9 PMID: 2144363
  7. Adenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in rats.
    J Virol. 1994 Jun;68(6):3917-24 PMID: 8189528
  8. Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.
    Genes Dev. 1994 Jan;8(2):190-202 PMID: 8299938
  9. Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase.
    Nature. 1991 Sep 12;353(6340):174-7 PMID: 1653904
  10. A SHORT DESCRIPTION OF THE ADENOVIRUS GROUP.
    Virology. 1963 Aug;20:613-20 PMID: 14059828
  11. The p53 proto-oncogene can act as a suppressor of transformation.
    Cell. 1989 Jun 30;57(7):1083-93 PMID: 2525423
  12. Thirty-one human adenovirus serotypes (Ad1-Ad31) form five groups (A-E) based upon DNA genome homologies.
    Virology. 1979 Mar;93(2):481-92 PMID: 452413
  13. Molecular genetics of the retinoblastoma suppressor gene.
    Crit Rev Oncog. 1991;2(3):211-27 PMID: 1888791
  14. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
    Cell. 1993 Nov 19;75(4):805-16 PMID: 8242751
  15. Nucleotide sequence of the right 10% of adenovirus type 12 DNA encoding the entire region E4.
    Nucleic Acids Res. 1990 May 25;18(10):3065-6 PMID: 2349112
  16. Human adenovirus type 9-induced rat mammary tumors.
    J Virol. 1991 Jun;65(6):3192-202 PMID: 2033670
  17. Efficient transformation of rat 3Y1 cells by human adenovirus type 9.
    Virology. 1984 Jul 30;136(2):328-37 PMID: 6205502
  18. Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein.
    Cell. 1991 Sep 20;66(6):1155-64 PMID: 1833063
  19. Nucleotide sequence of adenovirus 2 DNA fragment encoding for the carboxylic region of the fiber protein and the entire E4 region.
    Nucleic Acids Res. 1981 Aug 25;9(16):4023-42 PMID: 6985482
  20. Fibroadenoma: morphological observations and a theory of pathogenesis.
    Pathol Annu. 1994;29 Pt 1:1-19 PMID: 8127621
  21. Clonal analysis of fibroadenoma and phyllodes tumor of the breast.
    Cancer Res. 1993 Sep 1;53(17):4071-4 PMID: 8395336
  22. E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators.
    Cell. 1994 Jun 17;77(6):799-800 PMID: 8004670
  23. Adenovirus type 9-induced tumorigenesis in the rat mammary gland related to sex hormonal state.
    J Natl Cancer Inst. 1989 Feb 15;81(4):294-8 PMID: 2913327
  24. Studies on adenovirus type 9-induced mammary fibroadenomas in rats and their malignant transformation.
    Cancer. 1977 Jun;39(6):2513-9 PMID: 872051
  25. Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product.
    Nature. 1988 Jul 14;334(6178):124-9 PMID: 2968522
  26. Fibroadenoma and cystosarcoma phyllodes of the male breast.
    Mod Pathol. 1992 Mar;5(2):114-6 PMID: 1315437
  27. Enlarging occult fibroadenomas.
    Radiology. 1992 Jun;183(3):639-41 PMID: 1584911
  28. Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B.
    Nature. 1990 Aug 23;346(6286):760-3 PMID: 2143810
  29. Requirement for the adenovirus type 9 E4 region in production of mammary tumors.
    Science. 1992 Aug 28;257(5074):1267-71 PMID: 1519063
  30. Antigenic profile of mammary fibroadenoma and cystosarcoma phyllodes. A study using antibodies to estrogen- and progesterone receptors and to a panel of cell surface molecules.
    Pathol Res Pract. 1990 Aug;186(4):427-38 PMID: 2174150
  31. Functions of the adenovirus E1B tumour antigens.
    Cancer Surv. 1986;5(2):389-404 PMID: 2946407
  32. Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene.
    Science. 1990 Aug 31;249(4972):1049-51 PMID: 2144364
  33. Functional relatedness between the E1a and E1b regions of group C and group D human adenoviruses.
    Virus Res. 1987 Feb;7(1):33-48 PMID: 2951934
  34. Carcinoma arising within fibroadenomas of the breast. A clinicopathologic study of 105 patients.
    Am J Clin Pathol. 1991 May;95(5):614-22 PMID: 1850948
  35. WAF1, a potential mediator of p53 tumor suppression.
    Cell. 1993 Nov 19;75(4):817-25 PMID: 8242752
  36. E2F transcription factor is a target for the RB protein and the cyclin A protein.
    Cold Spring Harb Symp Quant Biol. 1991;56:157-62 PMID: 1840249
  37. Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.
    Genes Dev. 1993 Dec;7(12A):2378-91 PMID: 8253384
  38. Induction of mammary fibroadenomas in rats by adenovirus type 9.
    Int J Cancer. 1974 Mar 15;13(3):286-90 PMID: 4822103
  39. Adenovirus E1A targets key regulators of cell proliferation.
    Cancer Surv. 1992;12:161-95 PMID: 1353412
Article Info
Journal
Breast cancer research and treatment
Abbr.
Breast Cancer Res Treat
ISSN
0167-6806
DOI
10.1007/BF01806078
Published
1996-00-00
Pages
57-67
Language
English
Region
Netherlands
NLM ID
8111104
Subset
IM
Grants
NCI NIH HHS · R01 CA058541 · United States
NCI NIH HHS · CA41086 · United States
NCI NIH HHS · CA58541 · United States
Databases
GENBANK
S82508
External Links
PubMed source DOI: 10.1007/BF01806078 View journal details
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