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PMID: 8759835 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Fancy meeting you here! A fresh look at "prokaryotic" protein phosphorylation.

Journal of bacteriology ·Vol. 178 ·No. 16 ·1996-08-00 ·Pages 4759-64

Kennelly PJ, Potts M

Abstract

Bacteria play host to a wide range of protein phosphorylation-dephosphorylation systems (Fig. 1). As little as five years ago the known systems were thought to be late-emerging and absolutely prokaryote specific. Today we know that most protein kinases and protein phosphatases are descended from a set of common, and possibly quite ancient, prototypes. Prokaryote- and eukaryote-specific protein kinases and protein phosphatases are rare and represent exceptions, not the rule as previously thought. Commonality suggests that a dynamic and versatile regulatory mechanism was first adapted to the modulation of protein function as early if not earlier than more "basic" mechanisms such as allosterism, etc. The existence of common molecular themes confirms that the microbial world offers a unique, largely untapped library and a powerful set of tools for the understanding of a regulatory mechanism which is crucial to all organisms, tools whose diversity and experimental malleability will provide new avenues for exploring and understanding key modes of cellular regulation.

MeSH Terms
Animals Bacteria/classification,genetics,metabolism Bacterial Proteins/metabolism Cyanobacteria/genetics,metabolism Histidine Kinase Models, Biological Phosphoprotein Phosphatases/metabolism Phosphorylation Phylogeny Prokaryotic Cells/metabolism Protein Kinases/metabolism
Chemicals
Bacterial Proteins Protein Kinases Histidine Kinase Phosphoprotein Phosphatases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kennelly P J
Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0308, USA. [email protected]
Potts M
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.178.16.4759-4764.1996
Email
[email protected]
Published
1996-08-00
Pages
4759-64
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC178254
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.178.16.4759-4764.1996 PMC Full Text View journal details
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