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PMID: 8821094 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The role of fibroblasts in tumor behavior.

Cancer metastasis reviews ·Vol. 14 ·No. 4 ·1995-12-00 ·Pages 339-50

Grégoire M, Lieubeau B

Abstract

The prominent desmoplastic or stromal reaction seen in many invasive carcinomas suggests that stromal cells play a role in cancer pathogenesis. Investigations based on cell typing, using antibodies to cytoskeletal constituents, have revealed that most tumors contain various types of fibroblasts. Stromal cells with myofibroblastic differentiation features are the predominant cell type at the periphery of epithelial tumors. These tumor-activated fibroblasts play a major role in tumor development and spread, affecting the proliferation, differentiation, invasion or regression of cancer cells. This review considers the events inducing the different fibroblastic responses and the role of tumor-activated fibroblasts in both tumor development and anti-cancer treatments.

MeSH Terms
Cell Differentiation/physiology Cell Division/physiology Fibroblasts/physiology Humans Neoplasm Invasiveness Neoplasms/pathology Stromal Cells/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Grégoire M
Institut de Biologie, INSERM U419, Nantes, France.
Lieubeau B
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Article Info
Journal
Cancer metastasis reviews
Abbr.
Cancer Metastasis Rev
ISSN
0167-7659
DOI
10.1007/BF00690602
Published
1995-12-00
Pages
339-50
Language
English
Region
Netherlands
NLM ID
8605731
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00690602 View journal details
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